Wang Wei, Yang Ni, Yang Yu-Hang, Wen Ri, Liu Chun-Feng, Zhang Tie-Ning
Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.
J Inflamm Res. 2021 Sep 30;14:5023-5050. doi: 10.2147/JIR.S332840. eCollection 2021.
Emerging data indicates that non-coding RNAs (ncRNAs) represent more than just "junk sequences" of the genome and have been found to be involved in multiple diseases by regulating various biological process, including the activation of inflammasomes. As an important aspect of innate immunity, inflammasomes are large immune multiprotein complexes that tightly regulate the production of pro-inflammatory cytokines and mediate pyroptosis; the activation of the inflammasomes is a vital biological process in inflammatory diseases. Recent studies have emphasized the function of ncRNAs in the fine control of inflammasomes activation either by directly targeting components of the inflammasomes or by controlling the activity of various factors that control the activation of inflammasomes; consequently, ncRNAs may represent potential therapeutic targets for inflammatory diseases. Understanding the precise role of ncRNAs in controlling the activation of inflammasomes will help us to design targeted therapies for multiple inflammatory diseases. In this review, we summarize the regulatory role and therapeutic potential of ncRNAs in the activation of inflammasomes by focusing on a range of inflammatory diseases, including microbial infection, sterile inflammatory diseases, and fibrosis-related diseases. Our goal is to provide new ideas and perspectives for future research.
新出现的数据表明，非编码RNA（ncRNAs）并非仅仅是基因组的“垃圾序列”，而且已发现其通过调控包括炎性小体激活在内的各种生物学过程而参与多种疾病。作为固有免疫的一个重要方面，炎性小体是大型免疫多蛋白复合物，可严格调控促炎细胞因子的产生并介导细胞焦亡；炎性小体的激活是炎症性疾病中的一个重要生物学过程。最近的研究强调了ncRNAs在炎性小体激活的精细调控中的作用，其方式要么是直接靶向炎性小体的组分，要么是控制各种调控炎性小体激活的因子的活性；因此，ncRNAs可能代表炎症性疾病的潜在治疗靶点。了解ncRNAs在控制炎性小体激活中的精确作用将有助于我们设计针对多种炎症性疾病的靶向治疗方法。在本综述中，我们通过聚焦一系列炎症性疾病，包括微生物感染、无菌性炎症性疾病和纤维化相关疾病，总结了ncRNAs在炎性小体激活中的调控作用和治疗潜力。我们的目标是为未来的研究提供新的思路和观点。
