埃及冠心病患者3'载脂蛋白-VNTR的基因多态性
Gene polymorphism of 3'APO-VNTR in Egyptians with coronary artery disease.
作者信息
Elmougy Rehab
机构信息
Mansoura University, Faculty of Science, Chemistry Department, Division of Biochemistry, Mansoura, Egypt.
出版信息
J Med Biochem. 2021 Sep 3;40(4):390-394. doi: 10.5937/jomb0-30616.
BACKGROUND
Coronary artery diseases (CAD) are big health problem in both developed and developing countries. It is considered one of the main causes of death in the world. Dyslipidemia increases the risk of CAD incidences. It is aimed in this worktop study the impact of 3'APOBVNTRgene on CAD incidences.
METHODS
Eighty CAD patients and ninety-three healthy volunteers are enrolled in this study. Lipid parameters were estimated in both groups and PCR technique has been performed to analyze 3'APOB-VNTR gene polymorphism.
RESULTS
The genotypes 31/31, 31/37, 37/37 and 31/44 are more predominant in both groups. The frequency of 24/31 in CAD patients is (0.137) while it is completely absent in the control group. Our results show that there is an increase in the frequency of various genotypes (e.g., 17/31 and 21/34 genotypes) in the control group compared to theca patients group.
CONCLUSIONS
3'APOB-VNTR gene could probably be considered a risk factor for CAD incidences and may help to early diagnose them.
背景
冠状动脉疾病（CAD）在发达国家和发展中国家都是重大的健康问题。它被认为是全球主要死因之一。血脂异常会增加CAD发病风险。本研究旨在探讨3'APOBVNTR基因对CAD发病的影响。
方法
本研究纳入了80例CAD患者和93名健康志愿者。对两组患者的血脂参数进行了评估，并采用聚合酶链反应（PCR）技术分析3'APOB - VNTR基因多态性。
结果
31/31、31/37、37/37和31/44基因型在两组中更为常见。CAD患者中24/31基因型的频率为（0.137），而在对照组中完全不存在。我们的结果表明，与CAD患者组相比，对照组中各种基因型（如17/31和21/34基因型）的频率有所增加。
结论
3'APOB - VNTR基因可能被视为CAD发病的一个危险因素，并且可能有助于早期诊断CAD。
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