转移性尿路上皮癌：治疗格局迅速变化。

Metastatic Urothelial Cancer: a rapidly changing treatment landscape.

作者信息

Stecca Carlos, Abdeljalil Osama, Sridhar Srikala S

机构信息

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, ON, Canada.

Professor, University of Toronto, Medical Oncologist, Princess Margaret Cancer Center, Chair, GU Medical Oncologists of Canada, 7-625 -700 University Avenue, Toronto, ON M5G 2M9, Canada.

出版信息

Ther Adv Med Oncol. 2021 Sep 30;13:17588359211047352. doi: 10.1177/17588359211047352. eCollection 2021.

Despite significant progress, metastatic urothelial cancer remains an incurable condition with a limited life expectancy. Platinum-based chemotherapy is still the mainstay of treatment for metastatic disease, but immunotherapy, antibody drug conjugates, and targeted agents have shown encouraging results in several recent practice changing trials. In this review, we discuss the standard of care, recent therapeutic advances, ongoing clinical trials, and future perspectives in metastatic urothelial carcinoma.