Clasen Suparna C, Dinh Paul C, Hou Lifang, Fung Chunkit, Sesso Howard D, Travis Lois B
Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, Indiana University, 1800 N. Capitol Ave, E308, Indianapolis, IN, 46202, USA.
Division of Hematology-Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Cardiooncology. 2021 Oct 10;7(1):34. doi: 10.1186/s40959-021-00120-z.
Significantly increased risks of cardiovascular disease occur in testicular cancer survivors given cisplatin-based chemotherapy. The postulated mechanism of platinum-based chemotherapy's vascular toxicity has been thought secondary to its different early- and late- effects on vascular injury, endothelial dysfunction, and induction of a hypercoagulable state. We highlight for the first time the similarities between platinum-associated vascular adverse events and the vascular toxicity associated with other xenobiotic-metal contaminants. The vascular toxicity seen in large epidemiologic studies of testicular cancer survivors may in part be similar and mechanistically linked to the risk seen in environmental heavy metal contaminants linked to cardiovascular disease. Future research should be directed to better understand the magnitude of the adverse cardiovascular effects of platinum and to elucidate the underlying mechanisms of action.
接受以顺铂为基础的化疗的睾丸癌幸存者患心血管疾病的风险显著增加。铂类化疗药物血管毒性的假定机制被认为是继发于其对血管损伤、内皮功能障碍以及诱导高凝状态的不同早期和晚期影响。我们首次强调了铂相关血管不良事件与其他外源性金属污染物相关血管毒性之间的相似性。在睾丸癌幸存者的大型流行病学研究中观察到的血管毒性可能部分与环境重金属污染物导致的心血管疾病风险相似且存在机制上的联系。未来的研究应致力于更好地了解铂对心血管的不良影响程度，并阐明其潜在的作用机制。
