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通过 miR-1322/CCL20 轴和 M2 极化促进结直肠癌转移。

promotes colorectal cancer metastasis through miR-1322/CCL20 axis and M2 polarization.

机构信息

Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Institute of Gastroenterology, Zhejiang University, Hangzhou, China.

出版信息

Gut Microbes. 2021 Jan-Dec;13(1):1980347. doi: 10.1080/19490976.2021.1980347.

DOI:10.1080/19490976.2021.1980347
PMID:34632963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8510564/
Abstract

Colorectal cancer (CRC) is one of the most common malignant tumors and is associated with () infection. In this study, we explored the role of in the CRC metastasis. Our results showed that the abundance of was enriched in the feces and tumors of patients with CRC and tended to increase in stage IV compared to stage I in patients with metastatic CRC. Tumor-derived CCL20 activated by not only increases CRC metastasis, but also participates in the reprograming of the tumor microenvironment. promoted macrophage infiltration through CCL20 activation and simultaneously induced M2 macrophage polarization, enhancing the metastasis of CRC. In addition, we identified using database prediction and luciferase activity hat miR-1322, a candidate regulatory micro-RNA, could bind to CCL20 directly. infection decreased the expression of miR-1322 by activating the NF-κB signaling pathway in CRC cells. In conclusion, promotes CRC metastasis through the miR-1322/CCL20 axis and M2 polarization.

摘要

结直肠癌（CRC）是最常见的恶性肿瘤之一，与 () 感染有关。在本研究中，我们探讨了在 CRC 转移中的作用。我们的结果表明，在 CRC 患者的粪便和肿瘤中，的丰度富集，并且在转移性 CRC 患者中，与 I 期相比，其在 IV 期的趋势增加。肿瘤衍生的 CCL20 通过 激活不仅增加 CRC 转移，而且参与肿瘤微环境的重编程。通过 CCL20 激活促进巨噬细胞浸润，同时诱导 M2 巨噬细胞极化，增强 CRC 的转移。此外，我们通过数据库预测和荧光素酶活性鉴定出 miR-1322，一种候选调控 micro-RNA，可以直接与 CCL20 结合。在 CRC 细胞中，通过激活 NF-κB 信号通路，感染降低了 miR-1322 的表达。总之，通过 miR-1322/CCL20 轴和 M2 极化促进 CRC 转移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6777/8510564/5da57bfb100a/KGMI_A_1980347_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6777/8510564/98698ec4452e/KGMI_A_1980347_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6777/8510564/030786d79013/KGMI_A_1980347_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6777/8510564/1fdf34f11703/KGMI_A_1980347_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6777/8510564/56cd029e7bb6/KGMI_A_1980347_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6777/8510564/7e51622a58c1/KGMI_A_1980347_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6777/8510564/991936a4a9a8/KGMI_A_1980347_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6777/8510564/5da57bfb100a/KGMI_A_1980347_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6777/8510564/98698ec4452e/KGMI_A_1980347_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6777/8510564/030786d79013/KGMI_A_1980347_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6777/8510564/1fdf34f11703/KGMI_A_1980347_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6777/8510564/56cd029e7bb6/KGMI_A_1980347_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6777/8510564/7e51622a58c1/KGMI_A_1980347_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6777/8510564/991936a4a9a8/KGMI_A_1980347_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6777/8510564/5da57bfb100a/KGMI_A_1980347_F0007_OC.jpg

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[6]
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[8]
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本文引用的文献

[1]
Key chemokines direct migration of immune cells in solid tumors.

Cancer Gene Ther. 2022-1

[2]
Biological Implications and Clinical Potential of Metastasis-Related miRNA in Colorectal Cancer.

Mol Ther Nucleic Acids. 2020-10-22

[3]
The effect of miRNA and autophagy on colorectal cancer.

Cell Prolif. 2020-9-10

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The CCL20-CCR6 Axis in Cancer Progression.

Int J Mol Sci. 2020-7-22

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Ann Oncol. 2020-10

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Nucleic Acids Res. 2020-7-2

[7]
Circ-HOMER1 enhances the inhibition of miR-1322 on CXCL6 to regulate the growth and aggressiveness of hepatocellular carcinoma cells.

J Cell Biochem. 2020-11

[8]
promotes colorectal cancer metastasis by modulating /KRT7.

Gut Microbes. 2020-5-3

[9]
Tumor Microenvironment.

Medicina (Kaunas). 2019-12-30

[10]
TSLP Exacerbates Septic Inflammation via Murine Double Minute 2 (MDM2) Signaling Pathway.

J Clin Med. 2019-9-1

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