Bischoff W
Infection. 1986;14 Suppl 3:S209-10. doi: 10.1007/BF01667845.
120 women suffering from acute uncomplicated bacterial cystitis were treated in an open randomized study either with 1 X 400 mg enoxacin or 1 X 3 g amoxicillin per os. Analysis of midstream urine and bacteriological urine cultures were examined before, two and seven days as well as six weeks after therapy. Treatment with enoxacin resulted in 97.5% (second day), respectively 92.5% (seventh day) bacteriologically sterile urine cultures, whereas the rate of sterile urines following amoxicillin reached only 72.5% (second day), and 65% (seventh day), respectively. Side effects (gastrointestinal, allergic, cardiovascular) were noted in one case in the enoxacin group and in ten cases in the amoxicillin group. The highly active antibiotic derivatives of the 4-quinolone-group (e.g. enoxacin) administered as a single dose achieve high cure rates in carefully selected female patients with acute uncomplicated bacterial cystitis.
在一项开放性随机研究中，对120名患有急性单纯性细菌性膀胱炎的女性进行了治疗，她们分别口服1次400毫克依诺沙星或1次3克阿莫西林。在治疗前、治疗后两天和七天以及六周时对中段尿和尿细菌培养进行了检查。依诺沙星治疗使细菌学培养无菌尿的比例在第二天分别达到97.5%，在第七天达到92.5%，而阿莫西林治疗后无菌尿的比例仅分别为72.5%（第二天）和65%（第七天）。依诺沙星组有1例出现副作用（胃肠道、过敏、心血管方面），阿莫西林组有10例出现副作用。4-喹诺酮类的高活性抗生素衍生物（如依诺沙星）单剂量给药，在精心挑选的患有急性单纯性细菌性膀胱炎的女性患者中可达到高治愈率。
