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《血浆表皮生长因子受体变异检测分析前程序临床实践指南》。

Clinical Practice Guidelines for Pre-Analytical Procedures of Plasma Epidermal Growth Factor Receptor Variant Testing.

机构信息

Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.

Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

出版信息

Ann Lab Med. 2022 Mar 1;42(2):141-149. doi: 10.3343/alm.2022.42.2.141.

Abstract

Standardization of cell-free DNA (cfDNA) testing processes is necessary to obtain clinically reliable results. The pre-analytical phase of cfDNA testing greatly influences the results because of the low proportion and stability of circulating tumor DNA (ctDNA). In this review, we provide evidence-based clinical practice guidelines for pre-analytical phase procedures of plasma epidermal growth factor receptor gene () variant testing. Specific recommendations for pre-analytical procedures were proposed based on evidence from the literature and our experimental data. Standardization of pre-analytical procedures can improve the analytical performance of cfDNA testing.

摘要

cfDNA 检测过程的标准化对于获得可靠的临床结果是必要的。由于循环肿瘤 DNA(ctDNA)比例低且稳定性差,cfDNA 检测的分析前阶段对结果影响很大。在本综述中,我们提供了基于血浆表皮生长因子受体基因()变异检测分析前阶段程序的循证临床实践指南。根据文献证据和我们的实验数据,为分析前程序提出了具体建议。分析前程序的标准化可以提高 cfDNA 检测的分析性能。

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