地中海-得舒饮食干预神经退行性延迟（MIND）与老年人的身体功能和握力有关。
The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet is associated with physical function and grip strength in older men and women.
机构信息
Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA.
Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
出版信息
Am J Clin Nutr. 2022 Mar 4;115(3):625-632. doi: 10.1093/ajcn/nqab310.
BACKGROUND
Diet quality may be protective of physical function and muscle strength during aging.
OBJECTIVES
We aimed to investigate associations of the Mediterranean-Dietary Approaches to Stop Hypertension (DASH) Intervention for Neurodegenerative Delay (MIND) diet with physical function and grip strength.
METHODS
Data were obtained from men and women in the Baltimore Longitudinal Study of Aging (mean ± SD age: 68 ± 14 y at first diet visit; n = 1358). Diet was assessed by FFQ. MIND diet score was calculated from 15 food groups, with a higher score indicating better diet quality; tertile categories of averaged MIND score across visits were used. Physical function was assessed using the Short Physical Performance Battery (SPPB), with a score < 10 indicative of impaired function, and the Health, Aging and Body Composition Physical Performance Battery (HABCPPB). The highest value of grip strength over 3 trials was used. Multivariable logistic and linear mixed-effects models were examined with repeated measurements of physical function and grip strength, respectively.
RESULTS
MIND score was inversely associated with physical function impairment (per 1-point increment: OR: 0.81; 95% CI: 0.71, 0.93; P < 0.01), and with each SPPB component, over a median 6 y of follow-up. Participants in the highest compared with the lowest tertile of MIND diet score had 57% lower odds of functional impairment (OR: 0.43; 95% CI: 0.25, 0.73; P < 0.01), and slower decline by the HABCPPB. Men and women in the highest compared with the lowest tertiles of MIND score had 1.86-kg (95% CI: 0.33, 3.40 kg; P < 0.05) and 1.24-kg (95% CI: 0.04, 2.45 kg; P < 0.05) greater grip strength, respectively.
CONCLUSIONS
Adherence to the MIND dietary pattern was associated with lower odds of physical function impairment and decline, and with better muscle strength, indicating that the MIND dietary pattern may be protective of physical functional health in older adults.
背景
饮食质量可能对衰老过程中的身体功能和肌肉力量具有保护作用。
目的
我们旨在研究地中海-高血压膳食法（DASH）干预以阻止神经退行性疾病（MIND）饮食与身体功能和握力之间的关联。
方法
数据来自巴尔的摩纵向衰老研究（男性和女性；首次饮食访问时的平均年龄±标准差：68±14 岁；n=1358）。饮食通过 FFQ 进行评估。MIND 饮食评分是从 15 种食物组计算得出的，得分越高表示饮食质量越好；在整个访问期间，使用平均 MIND 评分的三分位数类别。身体功能使用简短身体表现电池（SPPB）进行评估，得分<10 表示功能受损，以及健康、衰老和身体成分身体表现电池（HABCPPB）。使用 3 次试验中握力的最高值。使用多变量逻辑和线性混合效应模型分别检查身体功能和握力的重复测量。
结果
MIND 评分与身体功能障碍呈负相关（每增加 1 分：OR：0.81；95%CI：0.71，0.93；P<0.01），并且与 SPPB 的每个组成部分相关，随访中位数为 6 年。与最低三分位组相比，MIND 饮食评分最高组的功能障碍的可能性低 57%（OR：0.43；95%CI：0.25，0.73；P<0.01），并且 HABCPPB 下降速度较慢。与最低三分位组相比，MIND 评分最高组的男性和女性握力分别增加 1.86 公斤（95%CI：0.33，3.40 公斤；P<0.05）和 1.24 公斤（95%CI：0.04，2.45 公斤；P<0.05）。
结论
遵守 MIND 饮食模式与身体功能障碍和下降的可能性降低以及肌肉力量增强相关，这表明 MIND 饮食模式可能对老年人的身体功能健康具有保护作用。
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