Department of Bioresources, School of Biological Sciences, University of Kashmir, Hazratbal, Srinagar, Jammu and Kashmir, 190005, India.
Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia; Princess Dr Najla Bint Saud Al- Saud Center for Excellence Research in Biotechnology, King Abdulaziz University, Jeddah, Saudi Arabia.
Chemosphere. 2022 Feb;288(Pt 2):132527. doi: 10.1016/j.chemosphere.2021.132527. Epub 2021 Oct 9.
The phytocomponent conjugated silver nanoparticles (AgNPs) have been extensively explored for various therapeutic applications such as antimicrobial, antioxidant, anticancer, anti-inflammatory, antidiabetic and anticoagulant effects. The bio-conjugation of Ag-based nanomaterial with plant extracts reduces their toxicity to biological systems and enhances their therapeutic effectiveness. The diversity of phytochemicals or capping agents provided by the plant extracts and the small size and large surface area of AgNPs permits maximum adsorption of these capping agents onto their surfaces that further promote the therapeutic performance of phytoconjugated AgNPs in various biomedical applications. The mechanistic action involved in antimicrobial and anticancer functions of AgNPs is mainly dependent on the induction of reactive oxygen species (ROS) resulting in cellular apoptosis and necrosis. This review summarizes the recent studies of various plant extract assisted synthesis of AgNPs, potential biomedical applications with the possible mechanism of action and major shortcomings affecting their therapeutic efficacy.
植物复合共轭银纳米粒子（AgNPs）已经被广泛探索用于各种治疗应用，如抗菌、抗氧化、抗癌、抗炎、抗糖尿病和抗凝血作用。Ag 基纳米材料与植物提取物的生物共轭降低了它们对生物系统的毒性，并提高了它们的治疗效果。植物提取物提供的植物化学成分或封端剂的多样性，以及 AgNPs 的小尺寸和大表面积，允许最大程度地将这些封端剂吸附到它们的表面上，从而进一步促进了在各种生物医学应用中植物共轭 AgNPs 的治疗性能。AgNPs 的抗菌和抗癌功能的作用机制主要取决于活性氧（ROS）的诱导，导致细胞凋亡和坏死。这篇综述总结了最近关于各种植物提取物辅助合成 AgNPs 的研究，以及它们在潜在的生物医学应用中的作用机制和影响其治疗效果的主要缺点。
