National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, 518036, People's Republic of China.
Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, 518036, People's Republic of China.
Biol Trace Elem Res. 2021 Feb;199(2):559-567. doi: 10.1007/s12011-020-02183-y. Epub 2020 May 24.
Bone marrow mesenchymal stem cells (MSCs) are multipotent stem cells with the ability to differentiate into bone-producing cells, which is essential for bone formation. Magnesium biomedical materials, such as biodegradable matters with osteoinductive properties, play a vital role in the osteogenic differentiation of MSCs. International and Chinese studies have shown that magnesium ions, which are produced by biodegradation, mainly achieve this effect by regulating the expression of genes and proteins associated with osteogenesis, activating multiple signal pathways, elevating autophagic activities, and adjusting the pH in the microenvironment. It is of great significance to study the regulatory mechanisms and identify the optimal conditions that how magnesium ions promote osteogenic differentiation of MSCs. In this study, we summarized the regulatory mechanisms noted above.
骨髓间充质干细胞（MSCs）是具有多向分化潜能的干细胞，能够分化为产生骨的细胞，这对于骨形成至关重要。镁生物医学材料，如具有成骨性的可生物降解物质，在 MSCs 的成骨分化中起着至关重要的作用。国际和国内的研究表明，由生物降解产生的镁离子主要通过调节与成骨相关的基因和蛋白质的表达，激活多个信号通路，提高自噬活性，以及调节微环境中的 pH 值来实现这一效果。研究镁离子如何促进 MSCs 的成骨分化的调控机制并确定最佳条件具有重要意义。在这项研究中，我们总结了上述的调控机制。
