The Joint Research Center of Guangzhou University and Keele Univeristy for Gene Interference and Application, School of Life Science, Guangzhou University, Guangzhou 510006, China.
Zhejiang Guoneng Technology Co., Ltd., 1518 Mengxi Road, Huzhou 313000, China.
Sensors (Basel). 2021 Sep 22;21(19):6326. doi: 10.3390/s21196326.
Hypochlorous acid (HOCl) generates from the reaction between hydrogen peroxide and chloride ions via myeloperoxidase (MPO)-mediated in vivo. As very important reactive oxygen species (ROS), hypochlorous acid (HOCl)/hypochlorite (OCl) play a crucial role in a variety of physiological and pathological processes. However, excessive or misplaced production of HOCl/OCl can cause variety of tissue damage and human diseases. Therefore, rapid, sensitive, and selective detection of OCl is very important. In recent years, the fluorescent probe method for detecting hypochlorous acid has been developed rapidly due to its simple operation, low toxicity, high sensitivity, and high selectivity. In this review, the progress of recently discovered fluorescent probes for the detection of hypochlorous acid was summarized with the aim to provide useful information for further design of better fluorescent probes.
次氯酸（HOCl）是由过氧化物和氯离子在髓过氧化物酶（MPO）介导的体内反应生成的。作为非常重要的活性氧（ROS），次氯酸（HOCl）/次氯酸盐（OCl）在各种生理和病理过程中起着至关重要的作用。然而，HOCl/OCl 的过度或错位产生会导致各种组织损伤和人类疾病。因此，快速、灵敏、选择性地检测 OCl 非常重要。近年来，由于操作简单、毒性低、灵敏度高、选择性好，用于检测次氯酸的荧光探针法发展迅速。本综述总结了近年来发现的用于检测次氯酸的荧光探针的研究进展，以期为进一步设计更好的荧光探针提供有价值的信息。
