稠环 6,5-并杂环系统中环六员碳的区域选择性 C-H 官能化反应研究进展概述。

Euromed Research Center, Euromed Faculty of Pharmacy, Euromed University of Fes, Route de Meknes, Fez 30000, Morocco.

Institute of Organic and Analytical Chemistry, University of Orleans, UMR CNRS 7311, BP 6759, CEDEX 2, 45067 Orleans, France.

Molecules. 2021 Sep 23;26(19):5763. doi: 10.3390/molecules26195763.

The regioselective C-H functionalization of the five-membered ring of the 6,5-fused heterocyclic systems is nowadays well documented due to its high reactivity compared to the six-membered ring. So, developing new procedures of C-H functionalization of the six-membered ring "by thinking out of the box" is extremely challenging, which explains the limited number of reports published to date. This review paper aims to highlight advances achieved in this emerging chemistry research and discusses recently reported methods.

由于与六元环相比，五元稠合杂环体系的 C-H 功能化具有较高的反应活性，因此其区域选择性 C-H 功能化现今已有大量文献记载。因此，要“跳出固有思维”开发六元环 C-H 功能化的新方法极具挑战性，这也解释了迄今为止发表的报道数量有限的原因。本文旨在强调该新兴化学研究领域的进展，并讨论最近报道的方法。