深共熔溶剂在 C-H 活化和交叉偶联反应中的应用潜力：综述。

Unlocking the Potential of Deep Eutectic Solvents for C-H Activation and Cross-Coupling Reactions: A Review.

机构信息

Euromed Research Center, Euromed Faculty of Pharmacy, School of Engineering in Biomedical and Biotechnology, Euromed University of Fes (UEMF), Meknes Road, Fez 30000, Morocco.

出版信息

Molecules. 2023 Jun 8;28(12):4651. doi: 10.3390/molecules28124651.

DOI:10.3390/molecules28124651

PMID:37375204

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10302773/

Abstract

Green chemistry principles have underpinned the development of deep eutectic solvents (DESs). In this brief overview, we discuss the potential of DESs as a greener alternative to volatile organic solvents for cross-coupling and C-H activation reactions in organic chemistry. DESs offer numerous benefits, such as easy preparation, low toxicity, high biodegradability, and the potential to replace volatile organic compounds. The ability of DESs to recover the catalyst-solvent system enhances their sustainability. This review highlights recent advances and challenges in utilizing DESs as a reaction media, as well as the impact of physicochemical properties on the reaction process. Several types of reactions are studied to highlight their effectiveness at promoting C-C bond formation. Aside from demonstrating the success of DESs in this context, this review also discusses the limitations and future prospects of DESs in organic chemistry.

摘要

绿色化学原则为深共晶溶剂（DESs）的发展提供了基础。在这篇简要综述中，我们讨论了 DESs 作为一种更环保的替代品，替代挥发性有机溶剂，用于有机化学中的交叉偶联和 C-H 活化反应的潜力。DESs 具有许多优点，例如易于制备、低毒性、高生物降解性，以及替代挥发性有机化合物的潜力。DESs 能够回收催化剂-溶剂体系，提高了它们的可持续性。本文综述了利用 DESs 作为反应介质的最新进展和挑战，以及物理化学性质对反应过程的影响。研究了几种类型的反应，以突出它们在促进 C-C 键形成方面的有效性。除了证明 DESs 在这方面的成功外，本文还讨论了 DESs 在有机化学中的局限性和未来前景。