Department of Family Medicine, Cheng Hsin General Hospital, Taipei, Taiwan.
Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Sci Rep. 2021 Oct 12;11(1):20267. doi: 10.1038/s41598-021-99767-y.
Metabolic syndrome (MetS) is associated with cardiovascular diseases, type 2 diabetes, chronic renal diseases, and all-cause mortality. Furthermore, MetS is associated with poor health-related quality of life (HRQOL). However, the impact of dynamic changes in MetS on changes in the HRQOL was not previously explored. This was an eight-year, prospective cohort study in which 906 middle-aged adults from Shipai, Taipei in northern Taiwan were enrolled during 2009-2010 (baseline). Of those sampled, 427 participants completed the follow-up investigation after 8 years. The HRQOL was measured using the Short Form Health Survey (SF-36). Other variables including age, sex, marital status, level of education, smoking, alcohol consumption, baseline body mass index, and changes in physical activity were adjusted. Compared with adults who never experienced MetS, adults with persistent MetS had a negative change in mental HRQOL (β - 4.20, 95% CI - 7.54 to - 0.86, p = 0.01). The negative changes of persistent MetS on the HRQOL were in the domains of vitality and mental health (β - 4.42, 95% CI - 8.10 to - 0.73 and β - 3.47, 95% CI - 6.90 to - 0.04, respectively). Women and overweight adults were vulnerable to the detrimental effects of persistent MetS. For better HRQOL, more resources should be devoted to reversing MetS in public health.
代谢综合征（MetS）与心血管疾病、2 型糖尿病、慢性肾脏疾病和全因死亡率有关。此外，MetS 与健康相关的生活质量（HRQOL）较差有关。然而，以前并未探讨 MetS 动态变化对 HRQOL 变化的影响。这是一项为期八年的前瞻性队列研究，在 2009-2010 年（基线）期间，从台北市北投市招募了 906 名中年成年人。在这些抽样中，427 名参与者在 8 年后完成了随访调查。使用简明健康调查量表（SF-36）测量 HRQOL。其他变量包括年龄、性别、婚姻状况、教育程度、吸烟、饮酒、基线体重指数以及身体活动的变化。与从未经历过 MetS 的成年人相比，持续患有 MetS 的成年人的心理健康 HRQOL 出现负向变化（β - 4.20，95%CI - 7.54 至 - 0.86，p = 0.01）。持续 MetS 对 HRQOL 的负向变化发生在活力和心理健康领域（β - 4.42，95%CI - 8.10 至 - 0.73 和β - 3.47，95%CI - 6.90 至 - 0.04）。女性和超重成年人更容易受到持续 MetS 的不利影响。为了提高 HRQOL，应在公共卫生领域投入更多资源来逆转 MetS。
