Kim D H, Kobashi K
Biochem Pharmacol. 1986 Oct 15;35(20):3507-10. doi: 10.1016/0006-2952(86)90619-2.
Arylsulfotransferase activity was found in the feces of human (14.74 +/- 2.674) and rat (7.37 +/- 1.126 mumol/hr/g wet feces). In the case of the rat, arylsulfotransferase activity was markedly and rapidly decreased by the treatment with antibiotics mixture, but restored to the original activity 3 weeks after stopping the administration of antibiotics. The excretion of the sulfate esters derived from p-nitrophenylsulfate was enhanced by the administration of acetaminophen but not by the treatment with antibiotics. Furthermore, in rats treated with antibiotics, inorganic sulfate excretion was severely decreased. When only acetaminophen was administered, the excretion of acetaminophen-O-sulfate showed a 10-15% decrease in rats treated with antibiotics compared with conventional rat.
在人类粪便中发现芳基硫酸转移酶活性为(14.74±2.674)，在大鼠粪便中为(7.37±1.126)μmol/小时/克湿粪便。对于大鼠，用抗生素混合物处理后芳基硫酸转移酶活性显著且迅速降低，但在停止使用抗生素3周后恢复到原始活性。对乙酰氨基酚的给药可增强对硝基苯硫酸酯衍生的硫酸酯的排泄，但抗生素处理则无此作用。此外，在用抗生素处理的大鼠中，无机硫酸盐排泄严重减少。仅给予对乙酰氨基酚时，与常规大鼠相比，用抗生素处理的大鼠中对乙酰氨基酚-O-硫酸盐的排泄减少了10-15%。
