Pérez-Bilbao Txomin, López-Tarruella Sara, Alonso-Dueñas María, San Juan Alejandro F, Ferreres-García Karla, Martín Miguel, Peinado Ana B, Rojo Federico
Health and Performance Department, Faculty of Physical Activity and Sports Sciences-INEF, Universidad Politécnica de Madrid, Madrid, Spain.
GEICAM Spanish Breast Cancer Group, Madrid, Spain.
Physiol Rep. 2025 Aug;13(16):e70511. doi: 10.14814/phy2.70511.
The purpose of this study was to determine the effects of a high-intensity interval-training (HIIT) or stretching-balance intervention 3 weeks prior to surgery in two hormone receptor-positive and human-epidermal growth-factor receptor 2-negative breast cancer patients. Patient 1 (58 years, stage IIA ductal carcinoma) performed a preoperative exercise program, and Patient 2 (63 years, stage IIB ductal carcinoma) underwent stretching-balance intervention. Tumor Ki67, body composition, oxygen uptake, inflammatory biomarkers, and psychological variables were measured before the intervention (T1), and prior to tumor resection (T2). Ki67 remained unchanged in Patient 2 and decreased by 28.6% in Patient 1. Patient 1 maintained her body mass (BM) and body mass index (BMI) with minor variation, while Patient 2 slightly increased her BM and BMI. Both patients increased their fat mass (FM) and %FM and decreased lean body mass (LBM) and %LBM, although to different extents. Peak oxygen uptake increased in Patient 1 and decreased in Patient 2. Interleukin-6 decreased, and C-reactive protein increased in both patients. Patient 1 showed a reduction in depressive symptoms, while Patient 2 exhibited no changes. Based on this case report, presurgical HIIT intervention appears to be a more promising exercise approach. However, larger scale-controlled studies will be needed.
本研究的目的是确定在手术前3周对两名激素受体阳性且人表皮生长因子受体2阴性的乳腺癌患者进行高强度间歇训练（HIIT）或伸展平衡干预的效果。患者1（58岁，IIA期导管癌）进行了术前锻炼计划，患者2（63岁，IIB期导管癌）接受了伸展平衡干预。在干预前（T1）以及肿瘤切除前（T2）测量肿瘤Ki67、身体成分、摄氧量、炎症生物标志物和心理变量。患者2的Ki67保持不变，患者1的Ki67下降了28.6%。患者1维持了其体重（BM）和体重指数（BMI），仅有微小变化，而患者2的BM和BMI略有增加。两名患者的脂肪量（FM）和%FM均增加，瘦体重（LBM）和%LBM均减少，尽管程度不同。患者1的峰值摄氧量增加，患者2的峰值摄氧量减少。两名患者的白细胞介素-6均下降，C反应蛋白均增加。患者1的抑郁症状减轻，而患者2没有变化。基于本病例报告，术前HIIT干预似乎是一种更有前景的锻炼方法。然而，还需要更大规模的对照研究。
