Department of Community Nutrition, School of Nutritional Sciences and Dietetics.
Students' Research Committee.
Am J Clin Nutr. 2018 Apr 1;107(4):593-606. doi: 10.1093/ajcn/nqx042.
To our knowledge, there is no study available that summarizes earlier findings on the effect of dietary glycemic index (GI) and glycemic load (GL) on inflammatory biomarkers.
This systematic review and meta-analysis was conducted to systematically review the available clinical trials that examined the effects of low-GI (LGI) and low-GL (LGL) diets on several inflammatory biomarkers in adults.
We searched for relevant articles published up to June 2017 through PubMed, Medline, SCOPUS, EMBASE, and Google Scholar with the use of relevant keywords. Clinical trials that examined the effect of dietary GI and GL on inflammation in adults were included.
Overall, 28 randomized controlled trials (RCTs) including 2961 participants (59% women, 41% men) were included in this meta-analysis. By combining findings from 14 studies on high-sensitivity C-reactive protein (hs-CRP) concentrations, we found no significant effect of LGI or LGL diets on serum hs-CRP concentrations compared with the control diet [weighted mean difference (WMD) for dietary GI: -0.05 mg/L (95% CI: -0.21, 0.10 mg/L); and WMD for dietary GL: 0.08 mg/L (95% CI: -0.26, 0.42 mg/L), respectively]. After combining effect sizes from 5 studies, we did not find significant changes in serum tumor necrosis factor α (TNF-α) concentrations comparing control diets with LGI (WMD: -0.18 mg/L; 95% CI: -0.43, 0.06 mg/L) or LGL (WMD: -0.20 mg/L; 95% CI: -0.33, 0.07 mg/L) diets. Significant changes were also not seen in leptin and interleukin 6 (IL-6) concentrations after the consumption of LGI or LGL diets.
We did not find any significant effect of dietary GI or GL on serum concentrations of inflammatory cytokines, including hs-CRP, leptin, IL-6, and TNF-α in adults. Additional RCTs-in particular, feeding trials-are required to shed light on this issue.
据我们所知，目前尚无研究总结饮食血糖指数（GI）和血糖负荷（GL）对炎症生物标志物影响的早期发现。
本系统评价和荟萃分析旨在系统回顾现有的临床试验，这些试验检查了低 GI（LGI）和低 GL（LGL）饮食对成年人几种炎症生物标志物的影响。
我们使用相关关键词，通过 PubMed、Medline、SCOPUS、EMBASE 和 Google Scholar 搜索截至 2017 年 6 月发表的相关文章。纳入了检查饮食 GI 和 GL 对成年人炎症影响的临床试验。
总体而言，该荟萃分析纳入了 28 项随机对照试验（RCT），共 2961 名参与者（59%为女性，41%为男性）。通过合并 14 项关于高敏 C 反应蛋白（hs-CRP）浓度的研究结果，我们发现与对照饮食相比，LGI 或 LGL 饮食对血清 hs-CRP 浓度没有显著影响[饮食 GI 的加权均数差（WMD）：-0.05mg/L（95%CI：-0.21，0.10mg/L）；饮食 GL 的 WMD：0.08mg/L（95%CI：-0.26，0.42mg/L）]。合并 5 项研究的效应量后，我们发现与对照饮食相比，LGI 或 LGL 饮食对血清肿瘤坏死因子-α（TNF-α）浓度没有显著变化（LGI：WMD：-0.18mg/L；95%CI：-0.43，0.06mg/L；LGL：WMD：-0.20mg/L；95%CI：-0.33，0.07mg/L）。在 LGI 或 LGL 饮食后，瘦素和白细胞介素 6（IL-6）浓度也没有显著变化。
我们没有发现饮食 GI 或 GL 对成年人血清炎症细胞因子（包括 hs-CRP、瘦素、IL-6 和 TNF-α）浓度有任何显著影响。需要更多的 RCT，特别是喂养试验，来阐明这个问题。
