中国汉族人群中、和雄激素受体的遗传多态性与慢性前列腺炎/慢性骨盆疼痛综合征。
Genetic Polymorphisms of , , and Androgen Receptor and Chronic Prostatitis/Chronic Pelvic Pain Syndrome in a Chinese Han Population.
机构信息
Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022 Anhui, China.
Institute of Urology, Anhui Medical University, Hefei, 230022 Anhui, China.
出版信息
Dis Markers. 2021 Oct 4;2021:2898336. doi: 10.1155/2021/2898336. eCollection 2021.
BACKGROUND
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) refers to a common disorder with unclear etiology and unsatisfactory treatment, which reduces the male's quality of life.
OBJECTIVE
To examine the effects of genetic polymorphisms of , , and androgen receptor () on CP/CPPS.
METHODS
The single nucleotide polymorphisms (SNPs) of , , and were genotyped with the improved multiplex ligation detection reaction. The GTEx, RegulomeDB, HaploReg, and 3DSNP databases were adopted to predict the regulatory functions of the genotyped SNPs. The correlation between SNPs and CP/CPPS was analyzed with the test, logistic regression, and two genetic models (codominant and log-additive models). The nomogram was built to predict the risk of CP/CPPS occurrence.
RESULTS
On the whole, 130 CP/CPPS patients and 125 healthy controls were recruited in the study, and 18 SNPs of , , and were genotyped. The results of functional annotation indicated that the 18 genotyped SNPs might have regulatory effects in the whole blood. The rs144488434 was correlated with the elevated CP/CPPS risk (odds ratio (OR): 2.40, 95% confidence interval (CI): 1.12-5.13, = 5.37, and = 0.021) by the test. In the built genetic models, rs10457655 was correlated with the elevated National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) scores (codominant model: GA/GG: crude mean difference (MD) = 0.98, 95% CI: -1.71-3.67 and AA/GG: crude MD = 9.10, 95% CI: 0.58-17.62, = 0.10). In subgroup analysis, rs2069718 was correlated with the elevated CP/CPPS risk (log-additive model: crude OR = 2.18, 95% CI: 1.03-4.64, and = 0.034) in patients ≥ 35 years. The nomogram integrating age, rs2069718, rs10457655, and rs144488434 showed good performance to predict the risk of CP/CPPS.
CONCLUSIONS
Genetic polymorphisms of , , and might act as the genetic factors for CP/CPPS susceptibility, which deserved further explorations.
背景
慢性前列腺炎/慢性骨盆疼痛综合征（CP/CPPS）是一种常见的疾病，病因不明，治疗效果不佳，降低了男性的生活质量。
目的
探讨基因多态性与 CP/CPPS 的关系。
方法
采用改良多重连接检测反应对基因进行单核苷酸多态性（SNP）分型。采用 GTEx、RegulomeDB、HaploReg 和 3DSNP 数据库预测基因分型 SNP 的调控功能。采用检验、Logistic 回归和两种遗传模型（共显性和对数加性模型）分析 SNP 与 CP/CPPS 的相关性。建立列线图预测 CP/CPPS 发生的风险。
结果
本研究共纳入 130 例 CP/CPPS 患者和 125 例健康对照者，对、和基因的 18 个 SNP 进行了基因分型。功能注释结果表明，18 个基因分型 SNP 可能在全血中具有调控作用。rs144488434 与 CP/CPPS 风险升高相关（比值比（OR）：2.40，95%置信区间（CI）：1.12-5.13，=5.37，=0.021）。在构建的遗传模型中，rs10457655 与 NIH-CPSI 评分升高相关（共显性模型：GA/GG：粗均数差异（MD）=0.98，95%CI：-1.71-3.67，AA/GG：粗 MD=9.10，95%CI：0.58-17.62，=0.10）。亚组分析显示，rs2069718 与≥35 岁患者 CP/CPPS 风险升高相关（对数加性模型：粗 OR=2.18，95%CI：1.03-4.64，=0.034）。整合年龄、rs2069718、rs10457655 和 rs144488434 的列线图对 CP/CPPS 风险的预测具有良好的性能。
结论
、和基因的多态性可能是 CP/CPPS 易感性的遗传因素，值得进一步探讨。
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