From the Departments of Ophthalmology, (Y.I., K.M., M.U., Y.M., K.I., Y.Y., C.S; Kyoto Prefectural University of Medicine, Kyoto, Japan; Oike-Ikeda Eye Clinic, Kyoto, Japan (Y.I., K.M.).
From the Departments of Ophthalmology, (Y.I., K.M., M.U., Y.M., K.I., Y.Y., C.S; Kyoto Prefectural University of Medicine, Kyoto, Japan; Oike-Ikeda Eye Clinic, Kyoto, Japan (Y.I., K.M.).
Am J Ophthalmol. 2022 Feb;234:235-240. doi: 10.1016/j.ajo.2021.10.001. Epub 2021 Oct 12.
To investigate the trend of seasonal variation of intraocular pressure (IOP) in patients with normal-tension glaucoma over a 20-year period by retrospectively analyzing the Kyoto Prefectural University of Medicine Glaucoma Registry database as real-world data.
Retrospective cohort study.
Data points (n = 49,007) were extracted retrospectively from the medical records of 1774 patients with normal-tension glaucoma (665 male patients and 1109 female patients; mean ± SD age was 59.8 ± 14.4 years; and mean ± SD observation period was 5.6 ± 4.4 years) seen over the 20-year period. We first calculated the mean IOP from all available data of each month from January 1997 through December 2016. The data were then categorized into 5 groups of 4 consecutive years each (1997-2000, 2001-2004, 2005-2008, 2009-2012, and 2013-2016) and the mean IOP of each month within the group was calculated. Seasonal variations of IOP over the 20-year study period and in the 5 consecutive groups were then investigated via nonlinear multiple regression analysis.
A continuous decrease of IOP was detected throughout the 20-year period (P < .001), with distinct seasonal variation. The annual mean ± SD IOP was highest (13.9 ± 2.7 mm Hg) in the oldest group (1997-2000), with a gradual decrease in each subsequent group, finally becoming lowest (12.3 ± 2.7 mm Hg) in the most recent group (2013-2016) (P < .001), and all of them were accompanied by distinct seasonal variation (P < .001).
Based on the Kyoto Prefectural University of Medicine Glaucoma Registry real-world longitudinal data, our findings revealed a continuous decrease and distinct seasonal variation of IOP in patients with normal-tension glaucoma throughout the 20-year study period.
通过回顾性分析京都府立医科大学青光眼登记数据库中的真实世界数据，研究 20 年来正常眼压性青光眼患者眼压的季节性变化趋势。
回顾性队列研究。
从 1774 例正常眼压性青光眼患者（665 例男性，1109 例女性；平均年龄±标准差为 59.8±14.4 岁；平均观察时间±标准差为 5.6±4.4 年）的病历中回顾性提取数据点（n=49007）。首先，我们计算了 1997 年 1 月至 2016 年 12 月每个月所有可用数据的平均眼压。然后，将数据分为 5 组，每组 4 年（1997-2000 年、2001-2004 年、2005-2008 年、2009-2012 年和 2013-2016 年），并计算组内每个月的平均眼压。然后通过非线性多元回归分析研究了 20 年研究期间和 5 个连续组内眼压的季节性变化。
整个 20 年期间，眼压呈持续下降趋势（P<.001），且具有明显的季节性变化。最年长组（1997-2000 年）的年平均±标准差眼压最高（13.9±2.7mmHg），随后的各组逐渐下降，最终在最近的组（2013-2016 年）达到最低（12.3±2.7mmHg）（P<.001），并且都伴随着明显的季节性变化（P<.001）。
基于京都府立医科大学青光眼登记真实世界纵向数据，我们的研究结果显示，20 年来正常眼压性青光眼患者的眼压呈持续下降趋势，且具有明显的季节性变化。
