Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon.
Cardiology Unit, Yaounde Central Hospital, Yaounde, Cameroon.
Pan Afr Med J. 2021 Sep 2;40:8. doi: 10.11604/pamj.2021.40.8.30855. eCollection 2021.
HIV infection is a well-known risk factor for stroke, especially in young adults. In Cameroon, there is a death of data on the outcome of stroke among persons living with HIV (PLWH). This study aimed to assess the cardiovascular risk profile and mortality in PLWH who had a stroke.
this was a retrospective cohort study of all PLWH aged ≥18 years admitted for stroke between January 2010 and December 2019 to the Cardiology Unit of the Yaoundé Central Hospital, Cameroon. Cardiovascular risk was estimated using the modified Framingham score, with subsequent dichotomization into low and intermediate/high risk. Mortality was assessed on day 7 during hospitalization (medical records), at one month, and one year by telephone call to a relative.
a total of 43 PLWH who had a stroke were enrolled. Their mean age was 52.1 (standard deviation 12.9) years, most of them were female (69.8%, n = 30). There were 25 (58.1%) patients on concomitant antiretroviral therapy. The Framingham cardiovascular risk score at admission was low in 29 patients (67.4%) and intermediate to high in 14 patients (32.6%). Ischemic stroke was the most common type of stroke in 36 persons (83.7%). The length of hospital stay was 11.4 (interquartile range 9.2-13.7) days. Mortality at 1 year was 46.5% (n = 20).
stroke mortality was high in this population of PLWH. Most patients had a low Framingham score, suggesting that this risk estimation tool underestimates cardiovascular risk in PLWH.
HIV 感染是中风的一个已知危险因素，尤其是在年轻人中。在喀麦隆，关于 HIV 感染者（PLWH）中风结局的数据缺失。本研究旨在评估发生中风的 PLWH 的心血管风险状况和死亡率。
这是一项回顾性队列研究，纳入了 2010 年 1 月至 2019 年 12 月期间在喀麦隆雅温得中心医院心内科因中风住院的所有年龄≥18 岁的 PLWH。使用改良的 Framingham 评分评估心血管风险，随后分为低危和中高危。住院期间（病历记录）第 7 天、1 个月和 1 年通过电话联系家属评估死亡率。
共纳入 43 例发生中风的 PLWH。他们的平均年龄为 52.1（标准差 12.9）岁，大多数为女性（69.8%，n=30）。有 25 名（58.1%）患者正在同时接受抗逆转录病毒治疗。入院时 Framingham 心血管风险评分低的患者有 29 例（67.4%），中高危的患者有 14 例（32.6%）。36 名患者（83.7%）为缺血性中风。住院时间为 11.4（四分位距 9.2-13.7）天。1 年死亡率为 46.5%（n=20）。
该 PLWH 人群的中风死亡率较高。大多数患者 Framingham 评分较低，表明该风险评估工具低估了 PLWH 的心血管风险。
