Foxp3和VISTA在宫颈癌中的表达及其临床病理意义
Expression and clinicopathological significance of Foxp3 and VISTA in cervical cancer.
作者信息
Li Li, Xu Xiao-Ting, Wang Li-Li, Qin Song-Bing, Zhou Ju-Ying
机构信息
Department of Radiation Oncology, The First Affiliated Hospital of Soochow University Suzhou 215006, China.
出版信息
Am J Transl Res. 2021 Sep 15;13(9):10428-10438. eCollection 2021.
Abstract
OBJECTIVE
To detect the expression differences of Foxp3 and VISTA in chronic cervical inflammation, cervical intraepithelial neoplasia, and cervical cancer, and to explore the role of Foxp3 and VISTA in the development of cervical cancer and the effect of Foxp3 and VISTA on the prognosis of cervical cancer, to provide a theoretical basis for clinical immunotherapy of cervical cancer.
METHODS
We collected 130 paraffin specimens of cervical tissue, which included 70 cases of cervical cancer tissue, 40 cases of cervical intraepithelial neoplasia tissues and 20 cases of chronic cervicitis. The expression of Foxp3 and VISTA in each group was detected, and the study was conducted based on the clinicopathological characteristics of the patients. The patients were followed up and the prognosis was statistically analyzed.
RESULT
- The expression of Foxp3 and VISTA was statistically different between the cervical cancer group and other groups. 2. Expressions of Foxp3 and VISTA were significantly correlated. 3. In 70 cases of cervical cancer, the expression of Foxp3 and VISTA was related to the clinical stage. 4. The 3-year survival rate of 70 patients with cervical cancer was 72.9%, and there were no factors affecting 3-year OS found. The expression of Foxp3 and VISTA was significantly correlated with the prognosis of cervical cancer. Foxp3 and VISTA double positive expression group had the worst prognosis.
CONCLUSION
- In cervical cancer, the expression of Foxp3 and VISTA was significantly higher than that of cervical intraepithelial neoplasia and chronic cervicitis, which suggested that they were closely related to the occurrence and growth of cervical cancer. 2. The expression of Foxp3 and VISTA was significantly related. 3. The positive expression of Foxp3 and VISTA could be used as independent prognostic factors for cervical cancer prognosis providing a strong basis for cervical cancer immunotherapy.
摘要
目的
检测Foxp3和VISTA在慢性宫颈炎、宫颈上皮内瘤变及宫颈癌中的表达差异，探讨Foxp3和VISTA在宫颈癌发生发展中的作用以及对宫颈癌预后的影响，为宫颈癌临床免疫治疗提供理论依据。
方法
收集130例宫颈组织石蜡标本，其中宫颈癌组织70例、宫颈上皮内瘤变组织40例、慢性宫颈炎组织20例。检测各组中Foxp3和VISTA的表达情况，并依据患者的临床病理特征进行研究。对患者进行随访并对预后进行统计学分析。
结果
- 宫颈癌组与其他组之间Foxp3和VISTA的表达存在统计学差异。2. Foxp3和VISTA的表达显著相关。3. 在70例宫颈癌中，Foxp3和VISTA的表达与临床分期有关。4. 70例宫颈癌患者的3年生存率为72.9%，未发现影响3年总生存期的因素。Foxp3和VISTA的表达与宫颈癌预后显著相关。Foxp3和VISTA双阳性表达组预后最差。
结论
- 在宫颈癌中，Foxp3和VISTA的表达显著高于宫颈上皮内瘤变和慢性宫颈炎，提示它们与宫颈癌的发生发展密切相关。2. Foxp3和VISTA的表达显著相关。3. Foxp3和VISTA的阳性表达可作为宫颈癌预后的独立预测因素，为宫颈癌免疫治疗提供有力依据。
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