Zhang Chunyan, Ren Dapeng, Ouyang Chifen, Wang Qinqin, Liu Ling, Zou Hong
Department of Respiratory and Critical Care Medicine, The People's Hospital of Kaizhou District Chongqing 405400, China.
Department of Anesthesiology, The People's Hospital of Kaizhou District Chongqing 405400, China.
Am J Transl Res. 2021 Sep 15;13(9):10793-10800. eCollection 2021.
To investigate the effects of standardized enteral nutrition (EN) on nutritional indicators and immunological functioning of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) patients with respiratory failure.
We selected 92 cases of AECOPD patients with respiratory failure as the research objects, and classified them into two groups (control/observation group, n=46 respectively) according to random number table. Both groups were given conventional anti-infection and symptomatic treatment. In addition, the control group received diet support therapy, and the observation group was given standard EN treatment. Afterwards, the changes of nutritional indicators, immunological functioning, inflammatory indicators and cardiopulmonary function of the two groups before and after therapy were compared.
Hemoglobin (HB), serum albumin (ALB), and total protein (TP) of the two groups after treatment were critically higher than those before treatment, and the indicators in observation group in post-treatment were remarkably higher than those in control group (); lymphocyte count (TLC), immunoglobulin A (IgA) and immunoglobulin G (IgG) of the two groups tremendously increased in post-treatment than before receiving treatment, and the post-treatment indicators of observation group were obviously higher than those of control group (); high sensitivity C-reactive protein (hs-CRP) and procalcitonin (PCT) in two groups sharply decreased after treatment comparing to which before treatment, and the observation group had notably lower post-treatment indexes than that of the control group (); Ejection minutes (LVEF), NT proBNP, partial pressure of carbon dioxide (PaCO), partial pressure of blood oxygen (PaO) and pH of the two groups had remarkably improved after treatment, and the improvement effect in observation group was superior to that in control group ().
The standard EN can substantially improve the nutritional status and immunological functioning of AECOPD patients with respiratory failure, reduce the inflammatory indicators, and promote their cardiopulmonary function.
探讨标准化肠内营养(EN)对慢性阻塞性肺疾病急性加重期(AECOPD)合并呼吸衰竭患者营养指标及免疫功能的影响。
选取92例AECOPD合并呼吸衰竭患者作为研究对象,根据随机数字表将其分为两组(对照组/观察组,各46例)。两组均给予常规抗感染及对症治疗。此外,对照组给予饮食支持治疗,观察组给予标准EN治疗。之后,比较两组治疗前后营养指标、免疫功能、炎症指标及心肺功能的变化。
两组治疗后血红蛋白(HB)、血清白蛋白(ALB)及总蛋白(TP)均显著高于治疗前,且观察组治疗后各项指标显著高于对照组();两组治疗后淋巴细胞计数(TLC)、免疫球蛋白A(IgA)及免疫球蛋白G(IgG)均较治疗前大幅升高,且观察组治疗后各项指标明显高于对照组();两组治疗后高敏C反应蛋白(hs-CRP)及降钙素原(PCT)较治疗前均大幅下降,且观察组治疗后指标显著低于对照组();两组治疗后射血分数(LVEF)、N末端脑钠肽前体(NT proBNP)、二氧化碳分压(PaCO)、血氧分压(PaO)及pH值均显著改善,且观察组改善效果优于对照组()。
标准EN可显著改善AECOPD合并呼吸衰竭患者的营养状况及免疫功能,降低炎症指标,促进其心肺功能。