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急性固体食物厌恶是新冠病毒相关嗅觉和味觉功能障碍的替代指标吗?

Is Acute Solid Food Aversion a Proxy for COVID-19-Related Olfactory and Gustatory Dysfunction?

作者信息

Tseng Farn-Hsuan, Yeh Sylvia H, Basiago Kevin, Miyares Wendy, Zangwill Kenneth M

机构信息

Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California.

Division of Pediatric Infectious Diseases, Harbor-UCLA Medical Center, Torrance California.

出版信息

Pediatrics. 2021 Oct 15;149(1). doi: 10.1542/peds.2021-052534.

Abstract

Olfactory and gustatory dysfunction (OGD) may be observed in adult and pediatric patients with coronavirus disease 2019 (COVID-19). In young preverbal patients, the presence of OGD may go undetected. We describe 2 children <2 years of age with acute solid food aversion most likely as a manifestation of OGD immediately after COVID-19 infection, with slow to minimal improvement over 6 to 8 months in both children. A review of the literature on COVID-19–related OGD in children is presented, revealing <100 cases and none associated with documented food aversion. We believe the presence of acute food aversion in preverbal children, in the appropriate epidemiological and clinical context, should trigger testing for COVID-19 because it may be the first and only symptom of infection and for pediatricians to provide anticipatory guidance for parents after acute COVID-19 infection in young children.

摘要

在患有2019冠状病毒病(COVID-19)的成人和儿童患者中,可能会观察到嗅觉和味觉功能障碍(OGD)。在年幼的学前期前儿童中,OGD的存在可能未被发现。我们描述了2名2岁以下的儿童,在感染COVID-19后立即出现急性固体食物厌恶,这很可能是OGD的一种表现,两名儿童在6至8个月内改善缓慢或几乎没有改善。本文对儿童中与COVID-19相关的OGD的文献进行了综述,发现相关病例不到100例,且均未记录有食物厌恶情况。我们认为,在适当的流行病学和临床背景下,学前期前儿童出现急性食物厌恶应引发对COVID-19的检测,因为这可能是感染的首个也是唯一症状,并且儿科医生应在幼儿急性感染COVID-19后为家长提供预期指导。

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