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小儿泌尿生殖系统微生物组:综述

The pediatric urobiome in genitourinary conditions: a narrative review.

机构信息

Department of Pediatrics, University of Pittsburgh School of Medicine, 4401 Penn Ave, Pittsburgh, PA, 15224, USA.

出版信息

Pediatr Nephrol. 2022 Jul;37(7):1443-1452. doi: 10.1007/s00467-021-05274-7. Epub 2021 Oct 15.

Abstract

The microbial ecosystem within the bladder that can be measured within the urine, or urobiome, is an emerging field of study with little published data regarding children. However, investigations into urobiome research have the potential to significantly impact the understanding of the pathophysiology of genitourinary conditions, as well as potentially identify novel therapeutics. Therefore, both researchers and clinicians should be aware of pediatric urobiome research. The purpose of this review is to highlight the literature around urobiome research in urinary tract infections, nephrolithiasis, and neurogenic bladder; comment on pediatric-specific considerations when reading and interpreting the urobiome literature; and to identify new potential areas of research.

摘要

膀胱内可在尿液中测量的微生物生态系统,即尿微生物组,是一个新兴的研究领域,关于儿童的数据很少。然而,对尿微生物组研究的调查有可能极大地促进对泌尿生殖系统疾病病理生理学的理解,并有可能确定新的治疗方法。因此,研究人员和临床医生都应该了解儿科尿微生物组研究。本文的目的是强调尿微生物组在尿路感染、肾结石和神经源性膀胱中的研究文献;评论在阅读和解释尿微生物组文献时与儿科相关的具体考虑因素;并确定新的潜在研究领域。

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