新冠病毒感染康复后肠道微生物群特征得到改善。
Improved gut microbiota features after the resolution of SARS‑CoV‑2 infection.
作者信息
De Maio Flavio, Ianiro Gianluca, Coppola Gaetano, Santopaolo Francesco, Abbate Valeria, Bianco Delia Mercedes, Del Zompo Fabio, De Matteis Giuseppe, Leo Massimo, Nesci Antonio, Nicoletti Alberto, Pompili Maurizio, Cammarota Giovanni, Posteraro Brunella, Sanguinetti Maurizio, Gasbarrini Antonio, Ponziani Francesca Romana
机构信息
Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy.
出版信息
Gut Pathog. 2021 Oct 16;13(1):62. doi: 10.1186/s13099-021-00459-9.
BACKGROUND
The severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) has a tropism for the gastrointestinal tract and several studies have shown an alteration of the gut microbiota in hospitalized infected patients. However, long-term data on microbiota changes after recovery are lacking.
METHODS
We enrolled 30 patients hospitalized for SARS‑CoV‑2-related pneumonia. Their gut microbiota was analyzed within 48 h from the admission and compared with (1) that of other patients admitted for suspected bacterial pneumonia (control group) (2) that obtained from the same subject 6 months after nasopharyngeal swab negativization.
RESULTS
Gut microbiota alpha-diversity increased 6 months after the resolution of SARS-CoV-2 infection. Bacteroidetes relative abundance was higher (≈ 36.8%) in patients with SARS-CoV-2, and declined to 18.7% when SARS-CoV-2 infection resolved (p = 0.004). Conversely, Firmicutes were prevalent (≈ 75%) in controls and in samples collected after SARS-CoV-2 infection resolution (p = 0.001). Ruminococcaceae, Lachnospiraceae and Blautia increased after SARS-CoV-2 infection resolution, rebalancing the gut microbiota composition.
CONCLUSION
SARS-CoV-2 infection is associated with changes in the gut microbiome, which tend to be reversed in long-term period.
背景
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）对胃肠道具有嗜性，多项研究表明，住院感染患者的肠道微生物群发生了改变。然而，缺乏关于康复后微生物群变化的长期数据。
方法
我们纳入了30例因SARS-CoV-2相关肺炎住院的患者。在入院后48小时内分析他们的肠道微生物群，并与（1）因疑似细菌性肺炎入院的其他患者（对照组）以及（2）在鼻咽拭子转阴6个月后从同一受试者获得的肠道微生物群进行比较。
结果
SARS-CoV-2感染消退6个月后，肠道微生物群的α多样性增加。SARS-CoV-2患者中拟杆菌门的相对丰度较高（约36.8%），当SARS-CoV-2感染消退时降至18.7%（p = 0.004）。相反，厚壁菌门在对照组和SARS-CoV-2感染消退后采集的样本中占主导地位（约75%）（p = 0.001）。在SARS-CoV-2感染消退后，瘤胃球菌科、毛螺菌科和布劳特氏菌属增加，使肠道微生物群组成重新平衡。
结论
SARS-CoV-2感染与肠道微生物组的变化有关，这种变化在长期内往往会逆转。
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