星形胶质细胞白细胞介素-3 预处理小胶质细胞。
Astrocyte interleukin-3 preps microglia.
机构信息
Center for Neuroimmunology and Neuroinfectious Diseases, Departments of Medicine, Pathology and Immunology, and Neuroscience, Washington University School of Medicine, St. Louis, MO, USA.
出版信息
Trends Immunol. 2021 Nov;42(11):937-939. doi: 10.1016/j.it.2021.09.008. Epub 2021 Oct 14.
Abstract
Brain β-amyloid (Aβ) deposition is a biomarker for Alzheimer's disease (AD) and other dementias, in which Aβ amounts correlate with disease burden. McAlpine et al. reveal that astrocyte expression or administration of interleukin (IL)-3 in the context of aggregated Aβ endows microglia with enhanced capability to cluster and clear Aβ oligomers.
摘要
脑β-淀粉样蛋白（Aβ）沉积是阿尔茨海默病（AD）和其他痴呆症的生物标志物，其中 Aβ 量与疾病负担相关。McAlpine 等人揭示了在聚集的 Aβ 背景下，星形胶质细胞表达或给予白细胞介素（IL）-3 使小胶质细胞具有增强的聚集和清除 Aβ 低聚物的能力。
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