Center for Neuroimmunology and Neuroinfectious Diseases, Departments of Medicine, Pathology and Immunology, and Neuroscience, Washington University School of Medicine, St. Louis, MO, USA.
Trends Immunol. 2021 Nov;42(11):937-939. doi: 10.1016/j.it.2021.09.008. Epub 2021 Oct 14.
Brain β-amyloid (Aβ) deposition is a biomarker for Alzheimer's disease (AD) and other dementias, in which Aβ amounts correlate with disease burden. McAlpine et al. reveal that astrocyte expression or administration of interleukin (IL)-3 in the context of aggregated Aβ endows microglia with enhanced capability to cluster and clear Aβ oligomers.
脑β-淀粉样蛋白（Aβ）沉积是阿尔茨海默病（AD）和其他痴呆症的生物标志物，其中 Aβ 量与疾病负担相关。McAlpine 等人揭示了在聚集的 Aβ 背景下，星形胶质细胞表达或给予白细胞介素（IL）-3 使小胶质细胞具有增强的聚集和清除 Aβ 低聚物的能力。
