适应和验证记忆改变测试（M@T）在希腊中年、老年和老年老年人群中，伴有主观认知减退和轻度认知障碍。

Adaptation and Validation of the Memory Alteration Test (M@T) in Greek Middle-Aged, Older, and Older-Old Population with Subjective Cognitive Decline and Mild Cognitive Impairment.

机构信息

Information Technologies Institute, Centre for Research and Technology Hellas, Thessaloniki, Greece.

1st Department of Neurology, G.H. "AHEPA", School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.

出版信息

J Alzheimers Dis. 2021;84(3):1219-1232. doi: 10.3233/JAD-210558.

DOI:10.3233/JAD-210558

PMID:34657882

Abstract

BACKGROUND

The Memory Alteration Test (M@T) is a verbal episodic and semantic memory screening test able to detect subjective cognitive decline (SCD) and Mild Cognitive Impairment (MCI).

OBJECTIVE

To adapt M@T, creating a Greek version of the Memory Alteration Test (M@T-GR), and to validate M@T-GR compared to the Mini-Mental State Examination (MMSE), and Subjective Cognitive Decline- Questionnaire (SCD-Q) MyCog and TheirCog.

METHODS

232 people over 55 years old participated in the study and they were classified as healthy controls (HC, n = 65), SCD (n = 78), or MCI (n = 89).

RESULTS

The ANCOVA showed that the M@T-GR's total score was significantly different in HC and SCD (I-J = 2.26, p = 0.032), HC and MCI (I-J = 6.16, p < 0.0001), and SCD compared to MCI (I-J = 3.90, p < 0.0001). In particular, a cut-off score of 46.50 points had an 81%sensitivity and 61%specificity for discriminating HC from SCD (AUC = 0.76, p < 0.0001), while a cut-off score of 45.50 had a sensitivity of 92%and a specificity of 73%for discriminating MCI (AUC = 0.88, p < 0.0001), and a cut-off score of 45.50 points had a sensitivity of 63%and a specificity of 73%for discriminating SCD from those with MCI (AUC = 0.69, p < 0.0021). Exploratory factor analysis indicated that there was one factor explaining 38.46%of the total variance. Internal consistency was adequate (α= 0.75), while convergent validity was found between M@T-GR and MMSE (r = 0.37, p < 0.0001) and SCD-Q TheirCog (r = -0.32, p < 0.0001).

CONCLUSION

The M@T-GR is a good to fair screening tool with adequate discriminant validity for administration in people with SCD and MCI in Greece.

摘要

背景

记忆改变测试（M@T）是一种能够检测主观认知下降（SCD）和轻度认知障碍（MCI）的口头情景和语义记忆筛查测试。

目的

将 M@T 改编为希腊语版的记忆改变测试（M@T-GR），并验证 M@T-GR 与简易精神状态检查（MMSE）和主观认知下降问卷（SCD-Q）的 MyCog 和 TheirCog 相比的有效性。

方法

共有 232 名 55 岁以上的人参与了这项研究，他们被分为健康对照组（HC，n=65）、SCD（n=78）或 MCI（n=89）。

结果

方差分析显示，M@T-GR 的总分在 HC 和 SCD（I-J=2.26，p=0.032）、HC 和 MCI（I-J=6.16，p<0.0001）以及 SCD 与 MCI 之间（I-J=3.90，p<0.0001）存在显著差异。特别是，46.50 分的截断值对区分 HC 和 SCD 的敏感性为 81%，特异性为 61%（AUC=0.76，p<0.0001），而 45.50 分的截断值对区分 MCI 的敏感性为 92%，特异性为 73%（AUC=0.88，p<0.0001），而 45.50 分的截断值对区分 SCD 和 MCI 的敏感性为 63%，特异性为 73%（AUC=0.69，p<0.0021）。探索性因子分析表明，有一个因子解释了总方差的 38.46%。内部一致性较好（α=0.75），同时在 M@T-GR 与 MMSE（r=0.37，p<0.0001）和 SCD-Q TheirCog（r=-0.32，p<0.0001）之间发现了收敛效度。