Information Technologies Institute, Centre for Research and Technology Hellas, Thessaloniki, Greece.
1st Department of Neurology, G.H. "AHEPA", School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
J Alzheimers Dis. 2021;84(3):1219-1232. doi: 10.3233/JAD-210558.
The Memory Alteration Test (M@T) is a verbal episodic and semantic memory screening test able to detect subjective cognitive decline (SCD) and Mild Cognitive Impairment (MCI).
To adapt M@T, creating a Greek version of the Memory Alteration Test (M@T-GR), and to validate M@T-GR compared to the Mini-Mental State Examination (MMSE), and Subjective Cognitive Decline- Questionnaire (SCD-Q) MyCog and TheirCog.
232 people over 55 years old participated in the study and they were classified as healthy controls (HC, n = 65), SCD (n = 78), or MCI (n = 89).
The ANCOVA showed that the M@T-GR's total score was significantly different in HC and SCD (I-J = 2.26, p = 0.032), HC and MCI (I-J = 6.16, p < 0.0001), and SCD compared to MCI (I-J = 3.90, p < 0.0001). In particular, a cut-off score of 46.50 points had an 81%sensitivity and 61%specificity for discriminating HC from SCD (AUC = 0.76, p < 0.0001), while a cut-off score of 45.50 had a sensitivity of 92%and a specificity of 73%for discriminating MCI (AUC = 0.88, p < 0.0001), and a cut-off score of 45.50 points had a sensitivity of 63%and a specificity of 73%for discriminating SCD from those with MCI (AUC = 0.69, p < 0.0021). Exploratory factor analysis indicated that there was one factor explaining 38.46%of the total variance. Internal consistency was adequate (α= 0.75), while convergent validity was found between M@T-GR and MMSE (r = 0.37, p < 0.0001) and SCD-Q TheirCog (r = -0.32, p < 0.0001).
The M@T-GR is a good to fair screening tool with adequate discriminant validity for administration in people with SCD and MCI in Greece.
记忆改变测试（M@T）是一种能够检测主观认知下降（SCD）和轻度认知障碍（MCI）的口头情景和语义记忆筛查测试。
将 M@T 改编为希腊语版的记忆改变测试（M@T-GR），并验证 M@T-GR 与简易精神状态检查（MMSE）和主观认知下降问卷（SCD-Q）的 MyCog 和 TheirCog 相比的有效性。
共有 232 名 55 岁以上的人参与了这项研究，他们被分为健康对照组（HC，n=65）、SCD（n=78）或 MCI（n=89）。
方差分析显示，M@T-GR 的总分在 HC 和 SCD（I-J=2.26，p=0.032）、HC 和 MCI（I-J=6.16，p<0.0001）以及 SCD 与 MCI 之间（I-J=3.90，p<0.0001）存在显著差异。特别是，46.50 分的截断值对区分 HC 和 SCD 的敏感性为 81%，特异性为 61%（AUC=0.76，p<0.0001），而 45.50 分的截断值对区分 MCI 的敏感性为 92%，特异性为 73%（AUC=0.88，p<0.0001），而 45.50 分的截断值对区分 SCD 和 MCI 的敏感性为 63%，特异性为 73%（AUC=0.69，p<0.0021）。探索性因子分析表明，有一个因子解释了总方差的 38.46%。内部一致性较好（α=0.75），同时在 M@T-GR 与 MMSE（r=0.37，p<0.0001）和 SCD-Q TheirCog（r=-0.32，p<0.0001）之间发现了收敛效度。
M@T-GR 是一种在希腊语人群中对 SCD 和 MCI 具有良好到中等判别效度的筛查工具。
