Fan Lingye, Wang Chunyan, Zhan Ping, Liu Yaofang
Department of Gynaecology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan, China.
Sichuan Treatment Center for Gynaecologic and Breast Diseases (Gynaecology), Luzhou 64600, Sichuan, China.
Int J Endocrinol. 2021 Oct 8;2021:2022938. doi: 10.1155/2021/2022938. eCollection 2021.
Polycystic ovary syndrome (PCOS) is a common endocrinopathy with high prevalence. miR-141-3p downregulation was reported in PCOS rats. This study intended to investigate miR-141-3p expression in serum of PCOS patients and its correlation with glucose and lipid metabolism. A total of 100 PCOS patients and 100 healthy controls were enrolled in this study. Clinical parameters and glucose and lipid indexes were analyzed. A 3-month fat reduction intervention was conducted to PCOS-obese patients. Expressions of miR-141-3p and PTEN were detected. WHR and levels of TG, HDL-C, FBG, FINS, HOMA- and HOMA-IR showed significant differences in PCOS patients. miR-141-3p was downregulated in PCOS patients. Area under ROC curve of miR-141-3p diagnosing PCOS-obese patients was 0.985 with specificity 95.35% and flexibility 93.33%. Levels of glucose and lipid metabolism indexes were increased while HDL-C level was decreased in miR-141-3p low expression group. Indexes of PCOS-obese patients were improved and miR-141-3p was upregulated after fat reduction intervention. PTEN was upregulated in PCOS patients and negatively correlated with miR-141-3p. In conclusion, miR-141-3p was downregulated in PCOS patients and had higher diagnostic value on PCOS and associated with glucose and lipid metabolism. miR-141-3p might play a role in glucose and lipid metabolism in PCOS-obese patients by targeting PTEN.
多囊卵巢综合征（PCOS）是一种常见的、患病率较高的内分泌疾病。据报道，PCOS大鼠中miR-141-3p表达下调。本研究旨在探讨PCOS患者血清中miR-141-3p的表达及其与糖脂代谢的相关性。本研究共纳入100例PCOS患者和100例健康对照者。分析了临床参数以及糖脂指标。对PCOS肥胖患者进行了为期3个月的减脂干预。检测了miR-141-3p和PTEN的表达。PCOS患者的腰臀比（WHR）以及甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、空腹血糖（FBG）、空腹胰岛素（FINS）、胰岛素抵抗指数（HOMA-IR）和胰岛素抵抗稳态模型评估（HOMA-）水平存在显著差异。PCOS患者中miR-141-3p表达下调。miR-141-3p诊断PCOS肥胖患者的ROC曲线下面积为0.985，特异性为95.35%，灵敏度为93.33%。在miR-141-3p低表达组中，糖脂代谢指标水平升高，而HDL-C水平降低。减脂干预后，PCOS肥胖患者的指标得到改善，miR-141-3p表达上调。PCOS患者中PTEN表达上调，且与miR-141-3p呈负相关。综上所述，PCOS患者中miR-141-3p表达下调，对PCOS具有较高的诊断价值，且与糖脂代谢相关。miR-141-3p可能通过靶向PTEN在PCOS肥胖患者的糖脂代谢中发挥作用。
