Turuk Jyotirmayee, Palo Subrata K, Rath Sonalika, Subhadra Subhra, Sabat Jyotsnamayee, Sahoo Prakash K, Panda Sailendra, Pati Sanghamitra
VRDL, ICMR-RMRC Bhubaneswar, Nalco Square, Odisha, India.
Department of Public Health, ICMR-RMRC Bhubaneswar, Odisha, India.
J Family Med Prim Care. 2021 Aug;10(8):2958-2963. doi: 10.4103/jfmpc.jfmpc_2380_20. Epub 2021 Aug 27.
Dengue has affected many countries globally. Two-fifths part of the world is at risk, which can be affected by dengue disease. In India, the dengue incidence has increased in the recent past and emerged as an important health problem in many states including Odisha. Dengue disease presents with atypical clinical symptoms when associated with other co-infections.
A facility-based longitudinal study was carried out over a period of 1 year to determine the dengue co-infection and its outcome. The suspected cases were clinically assessed following a standard case report format and serological investigations including serotyping were carried out.
33.6% samples were dengue positive of which 78.5% were positive for NS1 Ag, 26.6% positive for dengue IgM and 5.1% to both. Among the dengue positive cases, 60.9% were male and mean age was 31.52 (±17.03) years. High occurrence of cases was during May to November with maximum in August. Among the 975 dengue positives, 57 (5.8%) were found to have co-infection. Chikungunya was the most common co-infection in 71.9%, followed by herpes simplex (HSV) (7%) and other diseases. Fever was the most common presenting symptom (98.2%), followed by myalgia (91.2%), retro orbital pain (91.2%), pain abdomen (12.3%), rash/lesion (8.8%), burning micturition (5.3%), petechiae (1.7%) and pruritus (1.7%) among the co-infected cases.
All the four dengue serotypes were found to be circulating with DEN 2 as the most predominant one. About 5.8% of dengue cases have co-infection (mainly with Chikungunya) and clinically present with atypical signs and symptoms.
登革热已在全球许多国家造成影响。世界五分之二的地区面临风险，可能受到登革热疾病的影响。在印度，登革热发病率最近有所上升，并在包括奥里萨邦在内的许多邦成为一个重要的健康问题。当登革热疾病与其他合并感染相关时，会出现非典型临床症状。
进行了一项为期1年的基于机构的纵向研究，以确定登革热合并感染情况及其结果。按照标准病例报告格式对疑似病例进行临床评估，并进行包括血清分型在内的血清学调查。
33.6%的样本登革热呈阳性，其中78.5%的样本NS1抗原呈阳性，26.6%的样本登革热IgM呈阳性，5.1%的样本两者均呈阳性。在登革热阳性病例中，60.9%为男性，平均年龄为31.52（±17.03）岁。病例高发期为5月至11月，8月达到峰值。在975例登革热阳性病例中，57例（5.8%）被发现有合并感染。基孔肯雅热是最常见的合并感染，占71.9%，其次是单纯疱疹病毒（HSV）（7%）和其他疾病。在合并感染病例中，发热是最常见的症状（98.2%），其次是肌痛（91.2%）、眶后疼痛（91.2%）、腹痛（12.3%）、皮疹/皮损（8.8%）、尿痛（5.3%）、瘀点（1.7%）和瘙痒（1.7%）。
发现所有四种登革热血清型均在传播，其中DEN 2最为常见。约5.8%的登革热病例有合并感染（主要是与基孔肯雅热合并感染），临床上表现为非典型体征和症状。
