Zong Hui, Hu Binyang, Han Yang, Li Zuofeng, Zhang Xiaoyan
Research Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Philips Research China, Shanghai, China.
JMIR Ment Health. 2021 Nov 17;8(11):e33599. doi: 10.2196/33599.
Various instruments for patient screening and diagnosis have been developed for and applied in posttraumatic stress disorder (PTSD).
This study comprehensively investigates the prevalence and temporal trends of the most widely used instruments in PTSD-related studies.
A total of 1345 files of registered clinical trials from ClinicalTrials.gov and 9422 abstracts from the PubMed database from 2005 to 2020 were downloaded for this study. The instruments applied in clinical trials were manually annotated, and instruments in abstracts were recognized using exact string matching. The prevalence score of an instrument in a certain period was calculated as the number of studies divided by the number of instances of the instrument. By calculating the yearly prevalence index of each instrument, we conducted a trends analysis and compared the trends in index change between instruments.
A total of 4178 instrument synonyms were annotated, which were mapped to 1423 unique instruments. In the 16 years from 2005 to 2020, only 10 instruments were used more than once per year; the 4 most used instruments were the PTSD Checklist, the Clinician-Administered PTSD Disorder Scale, the Patient Health Questionnaire, and the Beck Depression Inventory. There were 18 instruments whose yearly prevalence index score exceeded 0.1 at least once during the 16 years. The changes in trends and time points of partial instruments in clinical trials and PubMed abstracts were highly consistent. The average time duration of a PTSD-related trial was 1495.5 days or approximately 4 years from submission to ClinicalTrial.gov to publication in a journal.
The application of widely accepted and appropriate instruments can help improve the reliability of research results in PTSD-related clinical studies. With extensive text data obtained from real clinical trials and published articles, we investigated and compared the usage of instruments in the PTSD research community.
已经开发了各种用于创伤后应激障碍（PTSD）患者筛查和诊断的工具并将其应用于该疾病。
本研究全面调查了PTSD相关研究中使用最广泛的工具的患病率和时间趋势。
本研究下载了ClinicalTrials.gov中1345份注册临床试验文件以及2005年至2020年PubMed数据库中的9422篇摘要。对临床试验中使用的工具进行人工注释，对摘要中的工具使用精确字符串匹配进行识别。某一时期某工具的患病率得分计算为研究数量除以该工具的使用实例数量。通过计算每个工具的年度患病率指数，我们进行了趋势分析并比较了不同工具之间的指数变化趋势。
共注释了4178个工具同义词，这些同义词被映射到1423种独特的工具。在2005年至2020年的16年中，每年使用超过一次 的工具只有10种；使用最多的4种工具是创伤后应激障碍检查表、临床医生管理的创伤后应激障碍量表、患者健康问卷和贝克抑郁量表。有18种工具在这16年中至少有一次年度患病率指数得分超过0.1。临床试验和PubMed摘要中部分工具的趋势和时间点变化高度一致。从提交到ClinicalTrials.gov到在期刊上发表，PTSD相关试验的平均持续时间为1495.5天或约4年。
应用广泛接受且合适的工具有助于提高PTSD相关临床研究结果的可靠性。通过从真实临床试验和已发表文章中获得的大量文本数据，我们调查并比较了PTSD研究领域中工具的使用情况。
