Smith A, Roberts C, van Haaften-Day C, den Dulk G, Russell P, Tattersall M H
Cancer Genet Cytogenet. 1987 Feb;24(2):231-42. doi: 10.1016/0165-4608(87)90104-x.
Six cell lines, established from four primary ovarian carcinomas were examined cytogenetically. The lines varied greatly in their chromosome complement. All cells from the lines were aneuploid, although one cell line contained two populations having a pseudodiploid and a pseudotetraploid modal chromosome number. Every chromosome group was involved with loss and gain of chromosomes, but some individual chromosomes were more prone to aneuploidy than others. Chromosome #6 was the most stable throughout. Structural changes gave rise to many marker chromosomes. Although most markers were random and the majority unidentifiable, some abnormalities of clonal origin were found. Deletions especially of chromosome #1, were the most common change. Further sequential studies may elicit the origin, stability, and timing of the chromosome abnormalities.
对从4例原发性卵巢癌建立的6个细胞系进行了细胞遗传学检查。这些细胞系的染色体组成差异很大。所有细胞系的细胞均为非整倍体，尽管其中一个细胞系包含两个群体，其假二倍体和假四倍体的众数染色体数目不同。每个染色体组都有染色体的丢失和增加，但有些个别染色体比其他染色体更容易出现非整倍体。6号染色体在整个过程中最稳定。结构变化产生了许多标记染色体。虽然大多数标记是随机的，且大多数无法识别，但发现了一些克隆起源的异常。尤其是1号染色体的缺失是最常见的变化。进一步的序列研究可能会揭示染色体异常的起源、稳定性和发生时间。
