慢性粒细胞白血病患者的人类Y染色体长度多态性

Length polymorphisms of the human Y chromosome in patients with chronic myelogenous leukemia.

作者信息

Verma R S, Thomas S, Coleman M, Silver R T, Dosik H

出版信息

Cancer Genet Cytogenet. 1987 Feb;24(2):295-7. doi: 10.1016/0165-4608(87)90111-7.

Abstract

The extent of length heteromorphisms of the human Y chromosomes was measured in 50 patients with chronic myelogenous leukemia and was compared with 50 normal controls. No significant difference (p greater than 0.05) in the size of the Y chromosome was noted between these two groups. These findings differ from an earlier investigation, where a longer heterochromatic segment of Y chromosome was noted in malignant tumors and it was stressed that constitutive heterochromatin plays a role in susceptibility of cancer. Present investigation, however, suggests that this is not the case in patients with chronic myelogenous leukemia.

摘要

对50例慢性粒细胞白血病患者的人类Y染色体长度异质性程度进行了测量，并与50名正常对照者进行了比较。两组之间Y染色体大小无显著差异（p大于0.05）。这些发现与早期的一项研究不同，早期研究发现恶性肿瘤中Y染色体的异染色质区段较长，并强调组成型异染色质在癌症易感性中起作用。然而，目前的研究表明，慢性粒细胞白血病患者并非如此。