Dhawan Shivani, Takiar Megha, Manocha Anish, Dhawan Rajan, Malhotra Ranjan, Gupta Jyoti
Department of Periodontology and Oral Implantology, Maharishi Markandeshwar College of Dental Sciences and Research, Maharishi Markandeshwar Deemed to be University, Ambala, Haryana, India.
Department of Conservative Dentistry and Endodontics, Maharishi Markandeshwar College of Dental Sciences and Research, Maharishi Markandeshwar University, Ambala, Haryana, India.
J Indian Soc Periodontol. 2021 Sep-Oct;25(5):411-417. doi: 10.4103/jisp.jisp_583_20. Epub 2021 Aug 30.
Guided tissue regeneration has recently been advocated in re-constructing soft-tissue dimensions in recession defects. Advancement in nanotechnology has led to increased zest for approaches such as electrospinning of biologically active; nanofibrous functionally graded regenerative membranes for periodontal tissue engineering. A functionally graded membrane (FGM) had been tailored by incorporating chitosan and nano-hydroxyapatite over Amnion membrane and used in gingival recession defects.
It was single-blind, randomized controlled study. Split-mouth study was conducted in nine patients and 22 sites with recession defects were selected. Sites were divided into Group A (Amnion membrane with coronal advanced flap) and Group B (FGM with coronal advanced flap).
Sites were assessed clinically by recording plaque index (PI), gingival index (GI), vertical recession defect depth (VRDD), relative clinical attachment level (CAL), and width of keratinized tissue at baseline, 3-6 months; and radiographically by recording linear bone growth by dentascan at baseline and 6 months.
Both groups showed statistically significant reduction in PI, GI and VRDD, and CAL and nonsignificant reduction in width of keratinized tissue at 3 and 6 months postoperatively. Group A showed statistically significant linear bone growth at 6 months. Group B also showed gain in linear bone growth at 6 months; however, result was statistically nonsignificant.
FGM had shown favorable results by enhancing bone growth while preventing the gingival tissue downgrowth.
引导组织再生术最近被提倡用于重建牙龈退缩缺损处的软组织维度。纳米技术的进步激发了人们对生物活性静电纺丝等方法的兴趣，例如用于牙周组织工程的纳米纤维功能梯度再生膜。通过在羊膜上加入壳聚糖和纳米羟基磷灰石制备了一种功能梯度膜（FGM），并将其用于牙龈退缩缺损。
这是一项单盲随机对照研究。对9名患者进行了分口研究，选择了22个有退缩缺损的部位。这些部位被分为A组（羊膜联合冠向推进瓣）和B组（功能梯度膜联合冠向推进瓣）。
在基线、3至6个月时通过记录菌斑指数（PI）、牙龈指数（GI）、垂直退缩缺损深度（VRDD）、相对临床附着水平（CAL）和角化组织宽度进行临床评估；在基线和6个月时通过Dentascan记录线性骨生长进行影像学评估。
两组在术后3个月和6个月时PI、GI和VRDD以及CAL均有统计学意义的降低，角化组织宽度有非统计学意义的降低。A组在6个月时显示出统计学意义的线性骨生长。B组在6个月时也显示出线性骨生长增加；然而，结果无统计学意义。
功能梯度膜通过促进骨生长同时防止牙龈组织向下生长显示出良好的效果。
