Gross Jane E, McCown Michael Y, Okorie Caroline U A, Bishay Lara C, Dy Fei J, Astudillo Carmen Leon, Muhlebach Marianne S, Abu-Nassar Sara, Chen Diana Y, Hossain Nazia, Wang Ruobing, Klouda Timothy, Martiniano Stacey L, Lenhart-Pendergrass Patricia, Kirkby Stephen, Ortenberg Robin, McSparron Jakob I, Wang Tisha, Hayes Margaret M, Çoruh Başak
National Jewish Health, Denver, Colorado.
Walter Reed National Military Medical Center, Bethesda, Maryland.
ATS Sch. 2021 Sep 8;2(3):452-467. doi: 10.34197/ats-scholar.2021-0034RE. eCollection 2021 Sep.
The following is a concise review of the Pediatric Pulmonary Medicine Core reviewing pediatric pulmonary infections, diagnostic assays, and imaging techniques presented at the 2021 American Thoracic Society Core Curriculum. Molecular methods have revolutionized microbiology. We highlight the need to collect appropriate samples for detection of specific pathogens or for panels and understand the limitations of the assays. Considerable progress has been made in imaging modalities for detecting pediatric pulmonary infections. Specifically, lung ultrasound and lung magnetic resonance imaging are promising radiation-free diagnostic tools, with results comparable with their radiation-exposing counterparts, for the evaluation and management of pulmonary infections. Clinicians caring for children with pulmonary disease should ensure that patients at risk for nontuberculous mycobacteria disease are identified and receive appropriate nontuberculous mycobacteria screening, monitoring, and treatment. Children with coronavirus disease (COVID-19) typically present with mild symptoms, but some may develop severe disease. Treatment is mainly supportive care, and most patients make a full recovery. Anticipatory guidance and appropriate counseling from pediatricians on social distancing and diagnostic testing remain vital to curbing the pandemic. The pediatric immunocompromised patient is at risk for invasive and opportunistic pulmonary infections. Prompt recognition of predisposing risk factors, combined with knowledge of clinical characteristics of microbial pathogens, can assist in the diagnosis and treatment of specific bacterial, viral, or fungal diseases.
以下是对儿科肺医学核心内容的简要回顾,涵盖了在2021年美国胸科学会核心课程中介绍的儿科肺部感染、诊断检测方法及成像技术。分子方法彻底改变了微生物学。我们强调为检测特定病原体或检测组合而采集合适样本的必要性,并了解这些检测方法的局限性。在检测儿科肺部感染的成像方式方面已取得了显著进展。具体而言,肺部超声和肺部磁共振成像作为无辐射的诊断工具颇具前景,在评估和管理肺部感染方面,其结果与有辐射暴露风险的同类检查相当。照顾患有肺部疾病儿童的临床医生应确保识别出有非结核分枝杆菌病风险的患者,并为其提供适当的非结核分枝杆菌筛查、监测和治疗。冠状病毒病(COVID - 19)患儿通常症状较轻,但部分患儿可能发展为重症疾病。治疗主要是支持性护理,大多数患者可完全康复。儿科医生在社交距离和诊断检测方面提供的预期指导及适当咨询,对于遏制疫情仍然至关重要。儿科免疫功能低下的患者有发生侵袭性和机会性肺部感染的风险。迅速识别易感风险因素,结合对微生物病原体临床特征的了解,有助于诊断和治疗特定的细菌、病毒或真菌疾病。