Department of Public Health and Welfare, Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Stockholm, Sweden.
Alzheimers Dement. 2022 Jul;18(7):1325-1334. doi: 10.1002/alz.12492. Epub 2021 Oct 20.
Lifestyle interventions may prevent cognitive decline, but the sufficient dose of intervention activities and lifestyle changes is unknown. We investigated how intervention adherence affects cognition in the FINGER trial (pre-specified subgroup analyses).
FINGER is a multicenter randomized controlled trial examining the efficacy of multidomain lifestyle intervention (ClinicalTrials.gov NCT01041989). A total of 1260 participants aged 60 to 77 with increased dementia risk were randomized to a lifestyle intervention and control groups. Percentage of completed intervention sessions, and change in multidomain lifestyle score (self-reported diet; physical, cognitive, and social activity; vascular risk) were examined in relation to change in Neuropsychological Test Battery (NTB) scores.
Active participation was associated with better trajectories in NTB total and all cognitive subdomains. Improvement in lifestyle was associated with improvement in NTB total and executive function.
Multidomain lifestyle changes are beneficial for cognitive functioning, but future interventions should be intensive enough, and supporting adherence is essential.
生活方式干预可能预防认知能力下降，但干预活动和生活方式改变的足够剂量尚不清楚。我们研究了干预依从性如何影响 FINGER 试验中的认知（预先指定的亚组分析）。
FINGER 是一项多中心随机对照试验，旨在检验多领域生活方式干预的疗效（ClinicalTrials.gov NCT01041989）。共有 1260 名年龄在 60 至 77 岁之间、痴呆风险增加的参与者被随机分配到生活方式干预组和对照组。检查了完成的干预课程的百分比，以及多维生活方式评分（自我报告的饮食；身体、认知和社会活动；血管风险）的变化与神经心理测试电池（NTB）评分的变化之间的关系。
积极参与与 NTB 总分和所有认知子领域的更好轨迹相关。生活方式的改善与 NTB 总分和执行功能的改善相关。
多领域生活方式的改变对认知功能有益，但未来的干预措施应该足够密集，支持依从性至关重要。
