Bernstein I L, Courtney L, Braget D J
Physiol Behav. 1986;38(2):159-63. doi: 10.1016/0031-9384(86)90149-6.
The development of learned aversions to the available diet has been shown to contribute to the anorexia and weight loss which accompany the growth of certain tumors, including the Leydig LTW(m) tumor. Estradiol infusions were found to closely mimic the effects on food intake and food preference seen after Leydig LTW(m) tumor implants. That is, reductions in food intake and the development of severe aversions to a target diet available during hormone infusions were seen. Lesions of the area postrema greatly attenuated these effects of estradiol infusions. Similar lesions have been shown to have parallel effects on the LTW(m) tumor syndrome. These findings strongly implicate the elevations of circulating estrogens which accompany the growth of LTW(m) tumors in generating the symptoms of anorexia and diet aversions.
对现有饮食产生习得性厌恶已被证明会导致厌食和体重减轻，这与某些肿瘤（包括睾丸间质LTW(m)肿瘤）的生长相伴。研究发现，注射雌二醇能密切模拟睾丸间质LTW(m)肿瘤植入后对食物摄入和食物偏好的影响。也就是说，在激素注射期间，食物摄入量减少，并且对可获得的目标饮食产生严重厌恶。最后区损伤极大地减弱了注射雌二醇的这些效应。类似的损伤已被证明对LTW(m)肿瘤综合征有类似作用。这些发现有力地表明，伴随LTW(m)肿瘤生长的循环雌激素升高会引发厌食和饮食厌恶症状。
