Mordes J P, Rossini A A
Science. 1981 Jul 31;213(4507):565-7. doi: 10.1126/science.6941477.
The transplantable Leydig cell tumor of Wistar rats, LTW(m), caused decreased food consumption and weight loss in the host within 2 weeks of implantation. The tumor was small, did not metastasize, and did not affect several parameters of biochemical function. When the tumors were removed, increases in food intake and body weight occurred within 72 hours and were sustained. Reimplantation of tumors caused anorexia to recur. Parabiotic pairs of rats with tumor in one partner also experienced weight loss. Those rats in parabiosis with tumor-bearing rats gained less weight than those in parabiosis with control rats. These observations suggest that the LTW(m) tumor causes anorexia and that this anorexia is mediated by a circulating substance.
可移植的Wistar大鼠睾丸间质细胞瘤LTW(m)，在植入宿主后2周内导致宿主食物摄入量减少和体重减轻。该肿瘤体积小，不发生转移，且不影响几个生化功能参数。当肿瘤被切除后，食物摄入量和体重在72小时内增加并持续。重新植入肿瘤会导致厌食症复发。联体的大鼠中，一方有肿瘤，另一方也会体重减轻。与携带肿瘤的大鼠联体的大鼠比与对照大鼠联体的大鼠体重增加得少。这些观察结果表明，LTW(m)肿瘤会导致厌食症，且这种厌食症是由一种循环物质介导的。
