Bernstein I L
Cancer. 1986 Oct 15;58(8 Suppl):1881-6. doi: 10.1002/1097-0142(19861015)58:8+<1881::aid-cncr2820581415>3.0.co;2-k.
Although the causes of cancer anorexia remain poorly understood, it now seems evident that the symptoms of appetite and weight loss which occur in cancer patients are multiply-determined. Thus, the actual causes of specific clinical problems will depend on the type of disease and treatment involved. This report examines research aimed at understanding the mechanisms responsible for cancer anorexia. Particular emphasis is placed on studies examining the contribution of learned food aversions to the anorexia induced by tumors and antitumor therapy. Evidence from the clinic and the laboratory indicates that learned food aversions occur as a result of the association of foods with symptoms induced by chemotherapy and/or tumor growth. The role these aversions play in the etiology of cancer anorexia is discussed and studies aimed at developing methods for preventing them are described.
尽管癌症厌食症的病因仍未完全明确，但现在看来，癌症患者出现的食欲和体重减轻症状是由多种因素决定的。因此，特定临床问题的实际病因将取决于所涉及的疾病类型和治疗方法。本报告审视了旨在了解癌症厌食症发病机制的研究。特别强调了对习得性食物厌恶在肿瘤和抗肿瘤治疗所致厌食症中作用的研究。临床和实验室证据表明，习得性食物厌恶是由于食物与化疗和/或肿瘤生长引起的症状相关联而产生的。本文讨论了这些厌恶在癌症厌食症病因学中的作用，并描述了旨在开发预防方法的研究。
