College of Life Sciences and Medicine, Zhejiang Sci-Tch University, Hangzhou 310018, China.
Mar Drugs. 2021 Sep 23;19(10):532. doi: 10.3390/md19100532.
lectin (AVL) is a C-type marine lectin produced by sponges. Our previous study demonstrated that genes encoding AVL enhanced the cytotoxic effect of oncolytic vaccinia virus (oncoVV) in a variety of cancer cells. In this study, the inhibitory effect of oncoVV-AVL on Hela S3 cervical cancer cells, a cell line with spheroidizing ability, was explored. The results showed that oncoVV-AVL could inhibit Hela S3 cells growth both in vivo and in vitro. Further investigation revealed that AVL increased the virus replication, promote the expression of OASL protein and stimulated the activation of Raf in Hela S3 cells. This study may provide insight into a novel way for the utilization of lection AVL.
凝集素（AVL）是一种由海绵产生的 C 型海洋凝集素。我们之前的研究表明，编码 AVL 的基因增强了溶瘤痘苗病毒（oncoVV）在多种癌细胞中的细胞毒性作用。在这项研究中，探索了 oncoVV-AVL 对具有球体形成能力的宫颈癌 Hela S3 细胞的抑制作用。结果表明，oncoVV-AVL 可抑制体内和体外的 Hela S3 细胞生长。进一步的研究表明，AVL 增加了病毒复制，促进了 OASL 蛋白的表达，并刺激了 Raf 在 Hela S3 细胞中的激活。这项研究可能为利用凝集素 AVL 提供新的思路。
