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凝集素诱导的 ROS 增强溶瘤痘苗病毒复制并诱导肝癌细胞凋亡。

ROS Induced by Lectin Enhance Oncolytic Vaccinia Virus Replication and Induce Apoptosis in Hepatocellular Carcinoma Cells.

机构信息

College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.

出版信息

Mar Drugs. 2024 Jun 30;22(7):307. doi: 10.3390/md22070307.

DOI:10.3390/md22070307
PMID:39057416
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11278381/
Abstract

Oncolytic virotherapy is expected to provide a new treatment strategy for cancer. lectin (AVL) is a Ca-dependent lectin receptor containing the conserved domain of C-type lectin and the hydrophobic N-terminal region, which can bind to the bird's nest glycoprotein and D-galactose. Our previous studies suggested that the oncolytic vaccinia virus (oncoVV) armed with the AVL gene exerted remarkable replication and antitumor effects in vitro and in vivo. In this study, we found that oncoVV-AVL may reprogram the metabolism of hepatocellular carcinoma cells to promote ROS, and elevated ROS subsequently promoted viral replication and induced apoptosis. This study will provide a new theoretical basis for the application of oncoVV-AVL in liver cancer.

摘要

溶瘤病毒治疗有望为癌症提供新的治疗策略。凝集素（AVL）是一种 Ca 依赖性凝集素受体，包含 C 型凝集素的保守结构域和疏水性的 N 端区域，可与鸟巢糖蛋白和 D-半乳糖结合。我们之前的研究表明，携带 AVL 基因的溶瘤痘苗病毒（oncoVV-AVL）在体外和体内均表现出显著的复制和抗肿瘤作用。本研究发现，oncoVV-AVL 可能会重新编程肝癌细胞的代谢以促进 ROS 的产生，而升高的 ROS 随后促进了病毒的复制并诱导了细胞凋亡。本研究将为 oncoVV-AVL 在肝癌中的应用提供新的理论基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f68d/11278381/1d465592178b/marinedrugs-22-00307-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f68d/11278381/f85372b2be41/marinedrugs-22-00307-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f68d/11278381/e07c6b2a5a16/marinedrugs-22-00307-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f68d/11278381/9a6a34631ff9/marinedrugs-22-00307-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f68d/11278381/81f6b4e514ac/marinedrugs-22-00307-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f68d/11278381/020f1d88e631/marinedrugs-22-00307-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f68d/11278381/400cc7ca8973/marinedrugs-22-00307-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f68d/11278381/1d465592178b/marinedrugs-22-00307-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f68d/11278381/f85372b2be41/marinedrugs-22-00307-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f68d/11278381/e07c6b2a5a16/marinedrugs-22-00307-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f68d/11278381/9a6a34631ff9/marinedrugs-22-00307-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f68d/11278381/81f6b4e514ac/marinedrugs-22-00307-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f68d/11278381/020f1d88e631/marinedrugs-22-00307-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f68d/11278381/400cc7ca8973/marinedrugs-22-00307-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f68d/11278381/1d465592178b/marinedrugs-22-00307-g007.jpg

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Oxidative stress and ROS-mediated cellular events in RSV infection: potential protective roles of antioxidants.氧化应激和 RSV 感染中的 ROS 介导的细胞事件：抗氧化剂的潜在保护作用。
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