College of Life Sciences and Medicine, Zhejiang Sci-Tch University, Hangzhou 310018, China.
Mar Drugs. 2022 Oct 26;20(11):667. doi: 10.3390/md20110667.
lectin (AVL) is a C-type marine lectin derived from sponges. Our previous study demonstrated that oncolytic vaccinia virus carrying AVL (oncoVV-AVL) significantly enhanced the cytotoxicity of oncoVV in cervical cancer, colorectal cancer and hepatocellular carcinoma through the activation of Ras/ERK, MAPK/ERK and PI3K/Akt signaling pathways. In this study, the inflammatory response induced by oncoVV-AVL in a hepatocellular carcinoma cell (HCC) model was investigated. The results showed that oncoVV-AVL increased the levels of inflammatory cytokines including IL-6, IL-8 and TNF-α through activating the AP-1 signaling pathway in HCC. This study provides novel insights into the utilization of lectin AVL in the field of cancer therapy.
凝集素 (AVL) 是一种源自海绵的 C 型海洋凝集素。我们之前的研究表明，携带 AVL 的溶瘤痘病毒 (oncoVV-AVL) 通过激活 Ras/ERK、MAPK/ERK 和 PI3K/Akt 信号通路，显著增强了 oncoVV 在宫颈癌、结直肠癌和肝癌中的细胞毒性。在这项研究中，研究了 oncoVV-AVL 在肝癌细胞 (HCC) 模型中引起的炎症反应。结果表明，oncoVV-AVL 通过激活 HCC 中的 AP-1 信号通路，增加了包括 IL-6、IL-8 和 TNF-α 在内的炎症细胞因子的水平。这项研究为凝集素 AVL 在癌症治疗领域的应用提供了新的见解。
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