Descamps Mélanie, Boucher Olivier, Nguyen Dang Khoa, Rouleau Isabelle
Département de psychologie, Université du Québec à Montréal, Montreal, QC H2X 3P2, Canada.
Centre de recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC H2X 0A9, Canada.
Brain Sci. 2021 Oct 3;11(10):1316. doi: 10.3390/brainsci11101316.
The insula is involved in a wide variety of functions, including social and emotional processing. Despite the numerous connections it shares with brain structures known to play a role in autobiographical memory (AM), little is known on the contribution of the insula to AM processing. The aim of the study was to examine emotional AM retrieval in patients with insular resection for drug-resistant epilepsy. Ten patients who underwent partial or complete insular resection (IR) were matched on age, sex, and education, to fifteen patients who underwent temporal lobectomy (TL), and to fifteen healthy controls. Participants were asked to recall four positive, four negative, and four neutral memories from their past using the autobiographical interview procedure. The results suggest that AM for emotional and neutral events after IR was comparable to that of healthy controls, whereas deficits were observed after TL. However, an independent examiner judged IR patients' memories as poorer than those of healthy controls on the episodic richness scale, suggesting a lack of some aspects of rich and vivid remembering. Furthermore, analysis on subjective self-rated scales revealed that, contrary to healthy controls, patients with IR judged their neutral memories as more emotional. This study suggests that AM is generally preserved after IR. However, given the small sample size and varied lesion location, one cannot totally exclude a potential role of specific insular sub-regions on some aspects of autobiographical memory. In addition, IR patients showed poor emotional judgment for neutral memories, which is congruent with previous findings of altered emotional processing in this population.
脑岛参与多种功能，包括社会和情感处理。尽管它与已知在自传体记忆（AM）中起作用的脑结构有众多联系，但关于脑岛对AM处理的贡献却知之甚少。本研究的目的是检查因耐药性癫痫接受脑岛切除术的患者的情感AM提取情况。10名接受部分或完全脑岛切除术（IR）的患者在年龄、性别和教育程度上与15名接受颞叶切除术（TL）的患者以及15名健康对照进行匹配。参与者被要求使用自传体访谈程序回忆他们过去的四段积极、四段消极和四段中性记忆。结果表明，IR后情感和中性事件的AM与健康对照相当，而TL后则观察到缺陷。然而，一名独立检查者在情节丰富度量表上判断IR患者的记忆比健康对照差，这表明在丰富生动的记忆方面存在某些不足。此外，主观自评量表分析显示，与健康对照相反，IR患者认为他们的中性记忆更具情感性。本研究表明，IR后AM通常得以保留。然而鉴于样本量小且病变位置各异，无法完全排除特定脑岛亚区域在自传体记忆某些方面的潜在作用。此外，IR患者对中性记忆的情感判断较差，这与该人群中情感处理改变的先前研究结果一致。
