Guidi Eleonora Elisa Alice, Gramenzi Alessandro, Persico Paola, Di Prinzio Roberta, Di Simone Daniele, Cornegliani Luisa
"Città di Torino" Veterinary Clinic, 10135 Turin, Italy.
Veterinary Teaching Hospital, Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy.
Animals (Basel). 2021 Oct 16;11(10):2985. doi: 10.3390/ani11102985.
an imbalance of the intestinal microbiota can cause health problems in the gastrointestinal tract and in other organs. Canine Atopic Dermatitis (CAD) is a genetically predisposed, inflammatory and pruritic allergic skin disease with multifactorial etiology and multimodal treatment. The aim of this study was to assess the effect of a nutraceutical product on Dysbiotic Index (DI) and the skin lesions of atopic dogs.
a nutraceutical product was administered to 32 dogs with CAD. The product was associated with a standardized hypoallergenic diet for 60 days; the dietary regimen continued for 120 days, while ongoing therapies remained unchanged. Values of Visual Analogic Scale (VAS), Canine Atopic Dermatitis Lesional Index (CADLI) and DI were evaluated on day 0, 60, 120.
all the 32 dogs showed a statistically significant decrease ( < 0.001) to V60 of VAS and CADLI, which persisted and increased to V120 when diet alone was continued. The decrease in the DI value was also statistically significant ( < 0.001).
the intake of nutraceutical associated with diet resulted in a decrease in the index of intestinal dysbiosis, with an improvement in the subjective severity of cutaneous lesions.
肠道微生物群失衡会导致胃肠道及其他器官出现健康问题。犬特应性皮炎（CAD）是一种具有遗传易感性、炎症性和瘙痒性的过敏性皮肤病，病因多因素且治疗方式多样。本研究旨在评估一种营养保健品对特应性犬的肠道微生物失调指数（DI）和皮肤病变的影响。
对32只患有CAD的犬给予一种营养保健品。该产品与标准化低敏饮食联合使用60天；饮食方案持续120天，同时正在进行的治疗保持不变。在第0天、60天、120天评估视觉模拟量表（VAS）、犬特应性皮炎皮损指数（CADLI）和DI的值。
所有32只犬的VAS和CADLI在第60天（V60）时均显示出统计学显著下降（<0.001），当仅继续饮食时，这种下降持续并在第120天（V120）时有所增加。DI值的下降也具有统计学显著性（<0.001）。
与饮食相关的营养保健品摄入导致肠道微生物失调指数降低，皮肤病变主观严重程度得到改善。
