Messina Laura, Bruno Fabio, Licata Patrizia, Paola Davide Di, Franco Gianluca, Marino Ylenia, Peritore Alessio Filippo, Cuzzocrea Salvatore, Gugliandolo Enrico, Crupi Rosalia
Department of Veterinary Science, University of Messina, 98168 Messina, Italy.
Department of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, 98166 Messina, Italy.
Animals (Basel). 2022 Jul 21;12(14):1848. doi: 10.3390/ani12141848.
Atopic dermatitis (AD) is an inflammatory and allergic disease, whose multifactorial etiopathogenesis is the consequence of the link between the genetic, immunological and environmental components. The complexity and difficulty in understanding the causes that trigger or exacerbate this pathology makes it difficult, once diagnosed, to proceed with a targeted and effective therapeutic process. Today, the new frontiers of research look to natural and innovative treatments to counteract the different manifestations of dermatitis. From this point of view, the mucus secreted by Muller has proven, since ancient times, to be able to neutralize skin diseases. To study canine atopic dermatitis (cAD), we used cell lines of canine epidermal keratinocytes (CPEK) that are optimal to understand the biological reactivity of keratinocytes in vitro. The data obtained from our study demonstrate the anti-inflammatory capacity of snail secretion filtrate (SSF) in counteracting the production of proinflammatory cytokines produced during cAD, highlighting the opportunities for further studies to be able to identify new, natural and safe treatments for cAD and to open new frontiers for veterinarians and owners.
特应性皮炎（AD）是一种炎症性过敏性疾病，其多因素病因是遗传、免疫和环境因素相互关联的结果。由于理解引发或加重该病症的病因具有复杂性和难度，一旦确诊，很难开展有针对性的有效治疗过程。如今，研究的新前沿着眼于采用天然和创新疗法来对抗皮炎的不同表现形式。从这一角度来看，自古以来就已证实，穆勒氏细胞分泌的黏液能够中和皮肤病。为了研究犬特应性皮炎（cAD），我们使用了犬表皮角质形成细胞（CPEK）细胞系，该细胞系对于在体外了解角质形成细胞的生物学反应性而言是最佳选择。我们研究获得的数据表明，蜗牛分泌液滤液（SSF）具有抗炎能力，可对抗cAD期间产生的促炎细胞因子，这凸显了开展进一步研究的机会，以便能够确定针对cAD的新型、天然且安全的治疗方法，并为兽医和犬主开辟新的前沿领域。
