Zhao Shubi, Luo Yiqun, Chang Zong, Liu Chenchen, Li Tong, Gan Lu, Huang Yong, Sun Qinchao
National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative InnovationCenter for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, Nanning, 530021, Guangxi, China.
Research Laboratory for Biomedical Optics and Molecular Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, Guangdong, China.
Nanoscale Res Lett. 2021 Nov 29;16(1):170. doi: 10.1186/s11671-021-03627-7.
The second near infrared window is considered to be the optimal optical window for medical imaging and therapy as its capability of deep tissue penetration. The preparation of the gold nanorods with long wavelength absorption and low cytotoxicity is still a challenge. A series gold nanorods with large aspect ratio have been synthesized. Strong plasma absorption in the second near infrared window from 1000 to 1300 nm could be observed. The biocompatibility of the synthesized gold nanorods is dramatically improved via coating by bovine serum albumin (BSA), while the optical properties of which remains. The breast cancer tumor-bearing mouse could be well treated by the prepared gold nanorods with the NIR-II light intensity as low as 0.75 W/cm. In summary, these results demonstrate the feasibility of using low illumination dose to treat tumor in the NIR-II region via the large aspect ratio gould nanoparticles.
第二近红外窗口因其具有深层组织穿透能力，被认为是医学成像和治疗的最佳光学窗口。制备具有长波长吸收和低细胞毒性的金纳米棒仍然是一个挑战。已经合成了一系列具有大纵横比的金纳米棒。在1000至1300nm的第二近红外窗口中可以观察到强烈的等离子体吸收。通过牛血清白蛋白（BSA）包被，合成的金纳米棒的生物相容性得到显著改善，同时其光学性质得以保留。制备的金纳米棒在近红外二区光强度低至0.75W/cm²时，可以很好地治疗荷乳腺癌肿瘤小鼠。总之，这些结果证明了通过大纵横比的金纳米颗粒在近红外二区使用低光照剂量治疗肿瘤的可行性。
