State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Genes (Basel). 2021 Sep 25;12(10):1504. doi: 10.3390/genes12101504.
The potential probiotic benefits of have received increasing attention recently. We used comparative genomic analysis to explore the differences in the genome and the physiological characteristics of isolated from the fecal samples of Chinese adults and infants. The relationships between genotypes and phenotypes were analyzed to assess the effects of isolation sources on the genetic variation of . The phylogenetic tree results indicated that the phylogeny of may be related to the geographical features of its isolation source. was found to have an open pan-genome and a conserved core genome. The genetic diversity of is mainly reflected in carbohydrate metabolism- and immune/competition-related factors, such as the glycoside hydrolase gene family, bacteriocin operons, antibiotic resistance genes, and clustered regularly interspaced short palindromic repeats (CRISPR)-Cas. Additionally, the type III A CRISPR-Cas system was discovered in for the first time. strains exhibited niche-specific characteristics, and the results of this study provide an improved understanding of the genetics of this species.
最近，人们越来越关注 的潜在益生菌益处。我们使用比较基因组分析来探索从中国成年人和婴儿粪便样本中分离出的 之间在基因组和生理特性上的差异。分析基因型和表型之间的关系，以评估分离源对 遗传变异的影响。系统发育树结果表明， 的系统发育可能与其分离源的地理特征有关。 被发现具有开放的泛基因组和保守的核心基因组。 的遗传多样性主要反映在碳水化合物代谢和免疫/竞争相关因素上，如糖苷水解酶基因家族、细菌素操纵子、抗生素抗性基因和成簇规律间隔短回文重复序列 (CRISPR)-Cas。此外，在 中首次发现了 III A 型 CRISPR-Cas 系统。 菌株表现出特定生态位的特征，本研究的结果提高了对该物种遗传学的认识。
