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在人为导致的快速环境变化背景下,以杜父鱼为模型对象研究噪声污染的性别相关影响。

Sex Associated Effects of Noise Pollution in Stone Sculpin () as a Model Object in the Context of Human-Induced Rapid Environmental Change.

作者信息

Sapozhnikova Yulia P, Koroleva Anastasia G, Yakhnenko Vera M, Khanaev Igor V, Glyzina Olga Yu, Avezova Tatyana N, Volkova Aleksandra A, Mushinskaya Angela V, Tyagun Marina L, Shagun Artem N, Makarov Mikhail M, Kirilchik Sergey V, Sudakov Nikolay P, Klimenkov Igor V, Sukhanova Lyubov V

机构信息

Limnological Institute SB RAS, 3 Ulan-Batorskaya, 664033 Irkutsk, Russia.

Institute of the Earth's Crust SB RAS, 128 Lermontova Street, 664033 Irkutsk, Russia.

出版信息

Biology (Basel). 2021 Oct 19;10(10):1063. doi: 10.3390/biology10101063.

Abstract

This work simulates the consequences of HIREC using stone sculpins as model organisms. Sex-dependent effects of long-term noise exposure at mean sound pressure levels of 160-179 dB re 1 μPa (SPL) were measured. We applied a multilevel approach to testing the stress response: a comparative analysis of the macula sacculi and an assessment of hematological and molecular stress responses. Noise exposure resulted in hair cell loss, changes in some cytometric parameters in blood, and an increase in the number of functionally active mitochondria in the red blood cells of males and its decrease in females, demonstrating a mitochondrial allostatic load and depletion of functional reserve. Finally, a statistically significant decrease in the telomerase activity of the auditory epithelium and a shortening of telomere length in the brain as molecular markers of stress were observed after noise exposure only in females. No significant decrease in telomerase activity and shortening of telomere length in nerve target tissues were observed in stressed males. However, we recorded an increase in the telomerase activity in male gonads. This sex-dependent difference in load may be associated with accelerated cellular aging in females and lower stress-related long-term risk in males. In this article, we discuss possible reasons for these noise-induced stress effects.

摘要

这项研究以石首鱼为模式生物模拟了高强度重复性应激(HIREC)的后果。测量了平均声压级为160 - 179分贝(相对于1微帕斯卡,即SPL)的长期噪声暴露的性别依赖性影响。我们采用了一种多层次方法来测试应激反应:对球囊斑进行比较分析,并评估血液学和分子应激反应。噪声暴露导致毛细胞损失、血液中一些细胞计数参数的变化,以及雄性红细胞中功能活跃线粒体数量增加而雌性减少,这表明存在线粒体适应性负荷和功能储备耗竭。最后,仅在雌性中观察到噪声暴露后作为应激分子标志物的听觉上皮端粒酶活性显著降低以及大脑端粒长度缩短。在应激雄性中未观察到神经靶组织中端粒酶活性显著降低和端粒长度缩短。然而,我们记录到雄性性腺中端粒酶活性增加。这种负荷的性别依赖性差异可能与雌性细胞衰老加速和雄性较低的应激相关长期风险有关。在本文中,我们讨论了这些噪声诱导应激效应的可能原因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f0e/8533501/c3c11528f815/biology-10-01063-g001.jpg

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