Zhang Li, Zhang Zhenying, Xu Lei, Zhang Xin
Department of Physical Education, China University of Mining and Technology, Beijing 100083, China.
Department of Food Science and Engineering, Ningbo University, Ningbo 315211, China.
Foods. 2021 Sep 29;10(10):2312. doi: 10.3390/foods10102312.
The human body is home to a complex community of dynamic equilibrium microbiota, including bacteria, fungi, parasites, and viruses. It is known that the gut microbiome plays a crucial role in regulating innate and adaptive immune responses, intestinal peristalsis, intestinal barrier homeostasis, nutrient uptake, and fat distribution. The complex relationship between the host and microbiome suggests that when this relationship is out of balance, the microbiome may contribute to disease development. The brain-gut-microbial axis is composed of many signal molecules, gastrointestinal mucosal cells, the vagus nerve, and blood-brain barrier, which plays an essential role in developing many diseases. The microbiome can influence the central nervous system function through the brain-gut axis; the central nervous system can also affect the composition and partial functions of the gut microbiome in the same way. Different dietary patterns, specific dietary components, and functional dietary factors can significantly affect intestinal flora's structure, composition, and function, thereby affecting human health. Based on the above, this paper reviewed the relationship between diet, intestinal flora, and human health, and the strategies to prevent mental illness through the dietary modification of intestinal microorganisms.
人体是一个复杂的动态平衡微生物群落的宿主,其中包括细菌、真菌、寄生虫和病毒。众所周知,肠道微生物群落在调节先天性和适应性免疫反应、肠道蠕动、肠道屏障稳态、营养吸收和脂肪分布方面发挥着关键作用。宿主与微生物群之间的复杂关系表明,当这种关系失衡时,微生物群可能会促进疾病的发展。脑-肠-微生物轴由许多信号分子、胃肠道黏膜细胞、迷走神经和血脑屏障组成,在许多疾病的发生发展中起着至关重要的作用。微生物群可通过脑-肠轴影响中枢神经系统功能;中枢神经系统也能以同样的方式影响肠道微生物群的组成和部分功能。不同的饮食模式、特定的饮食成分和功能性饮食因素可显著影响肠道菌群的结构、组成和功能,从而影响人类健康。基于上述内容,本文综述了饮食、肠道菌群与人类健康之间的关系,以及通过对肠道微生物进行饮食调节来预防精神疾病的策略。