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微生物组法医生物样本库:迈向用于法医人类识别的微生物特征分析的一步。

Microbiome Forensic Biobanking: A Step toward Microbial Profiling for Forensic Human Identification.

作者信息

Caenazzo Luciana, Tozzo Pamela

机构信息

Laboratory of Forensic Genetics, Department of Molecular Medicine, University of Padova, 35121 Padova, Italy.

出版信息

Healthcare (Basel). 2021 Oct 14;9(10):1371. doi: 10.3390/healthcare9101371.

Abstract

In recent years many studies have highlighted the great potential of microbial analysis in human identification for forensic purposes, with important differences in microbial community composition and function across different people and locations, showing a certain degree of uncertainty. Therefore, further studies are necessary to enable forensic scientists to evaluate the risk of microbial transfer and recovery from various items and to further critically evaluate the suitability of current human DNA recovery protocols for human microbial profiling for identification purposes. While the establishment and development of microbiome research biobanks for clinical applications is already very structured, the development of studies on the applicability of microbiome biobanks for forensic purposes is still in its infancy. The creation of large population microbiome biobanks, specifically dedicated to forensic human identification, could be worthwhile. This could also be useful to increase the practical applications of forensic microbiology for identification purposes, given that this type of evidence is currently absent from most real casework investigations and judicial proceedings in courts.

摘要

近年来,许多研究强调了微生物分析在法医人类识别中的巨大潜力,不同人和地点的微生物群落组成和功能存在重要差异,存在一定程度的不确定性。因此,有必要进行进一步研究,以使法医科学家能够评估微生物从各种物品转移和恢复的风险,并进一步批判性地评估当前用于人类微生物谱分析以进行识别目的的人类DNA恢复方案的适用性。虽然用于临床应用的微生物组研究生物样本库的建立和发展已经非常完善,但用于法医目的的微生物组生物样本库适用性研究仍处于起步阶段。创建专门用于法医人类识别的大规模人群微生物组生物样本库可能是值得的。鉴于目前大多数实际案件调查和法庭司法程序中都缺乏这类证据,这对于增加法医微生物学在识别目的方面的实际应用也可能是有用的。

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Forensic Applications of Microbiomics: A Review.微生物组学的法医学应用:综述
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Gut microbiota in human metabolic health and disease.人体肠道微生物群与代谢健康和疾病。
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