一项新婴儿配方奶粉用于功能性胃肠疾病婴儿的观察性真实世界研究。
An Observational Real-Life Study with a New Infant Formula in Infants with Functional Gastro-Intestinal Disorders.
机构信息
KidZ Health Castle, Vrije Universiteit Brussel (VUB), UZ Brussel, 1090 Brussels, Belgium.
IQVIA, 1930 Zaventem, Belgium.
出版信息
Nutrients. 2021 Sep 23;13(10):3336. doi: 10.3390/nu13103336.
Abstract
Functional gastro-intestinal disorders (FGIDs) impair the quality of life of many infants and their families. A formula with partial whey hydrolysate, starch, high magnesium content, prebiotic fructo-oligosaccharide and galacto-oligosaccharide and the probiotic DSM 17938 was given during two weeks to 196 infants with at least two FGIDs. The efficacy was evaluated with the Cow Milk-associated Symptom Score (CoMiSS) and quality of life with the QUALIN score. The formula was shown to decrease FGIDs within three days (decrease of CoMiSS -1.29 (3.15) (mean (SD), < 0.0001) followed by an improvement of quality of life after seven days (increase QUALIN +1.4 (7.8); : 0.008). Constipation decreased from 18.8% to 6.5% within three days. In combination with reassurance and guidance, the nutritional intervention was shown to be effective in infants with FGIDS in real-life circumstances.
摘要
功能性胃肠疾病（FGIDs）会降低许多婴儿及其家庭的生活质量。在两周的时间里，196 名至少患有两种 FGIDs 的婴儿接受了含有部分乳清水解物、淀粉、高镁含量、益生元果寡糖和半乳糖寡糖以及益生菌 DSM 17938 的配方奶粉。采用牛奶相关症状评分（CoMiSS）评估疗效，采用生活质量评分（QUALIN）评估生活质量。结果表明，该配方奶粉在三天内可减少 FGIDs（CoMiSS 评分降低 -1.29（3.15）（均值（SD），<0.0001），随后在七天后生活质量得到改善（QUALIN 评分增加 +1.4（7.8）；：0.008）。便秘在三天内从 18.8%降至 6.5%。在提供安慰和指导的同时，营养干预在真实情况下对 FGIDs 婴儿有效。
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